G6PC Antikörper (N-Term)

Produktnummer ABIN2781769

Produktdetails anti-G6PC Antikörper

Target: G6PC (Glucose 6-Phosphatase, Catalytic (G6PC))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Meerschweinchen, Pferd, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser G6PC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: DFGIQSTRYL QVNYQDSQDW FILVSVIADL RNAFYVLFPI WFHLKETVGI

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 86%, Human: 100%, Mouse: 93%, Rabbit: 85%, Rat: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against G6pc. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide corresponding to a region of Mouse

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 357 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-G6PC Antikörper (ABIN2781769)

Lu, Wang, Jiang, Zhang, Wang, Sha, Chen, Lei, Liu: "Berberine inhibits gluconeogenesis in spontaneous diabetic rats by regulating the AKT/MAPK/NO/cGMP/PKG signaling pathway." in: Molecular and cellular biochemistry, (2023) (PubMed).

Wang, Ji, Zhang, Zhao, Yan, Zhang, Shen, Yang, Fang, Tian, Zhu, Gong, Zhang, Wei, Wang, Li, Wan, Xie, She, Wang, Huang, Li: "Targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates." in: Nature medicine, Vol. 23, Issue 4, pp. 439-449, (2017) (PubMed).

Wang, Zhang, Luo, Jiang, Zhang, Guo, Zhao, Zhu, Zhang, Yang, Li: "Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling." in: Nature communications, Vol. 7, pp. 10592, (2016) (PubMed).

Details zu G6PC

Target: G6PC (Glucose 6-Phosphatase, Catalytic (G6PC))

Andere Bezeichnung: G6pc (G6PC Produkte)

Hintergrund: G6pc hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. It forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels.
Alias Symbols: AW107337, G6Pase, G6pt, Glc-6-Pase
Protein Interaction Partner: Ppargc1a, Foxo1, Sirt1,
Protein Size: 357

Molekulargewicht: 40 kDa

Gen-ID: 14377

NCBI Accession: NM_008061, NP_032087

UniProt: P35576

Pathways: Carbohydrate Homeostasis, Cellular Glucan Metabolic Process