OPTN Antikörper (C-Term)

Produktnummer ABIN2781486

Dieses Anti-OPTN-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von OPTN in WB. Geeignet für Human, Maus, Ratte, Hund, Meerschweinchen, Rind (Kuh), Pferd, Kaninchen und Zebrafisch (Danio rerio).

Kurzübersicht für OPTN Antikörper (C-Term) (ABIN2781486)

Target: OPTN (Optineurin (OPTN))

Reaktivität: Human, Maus, Ratte, Hund, Meerschweinchen, Rind (Kuh), Pferd, Kaninchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser OPTN Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-OPTN Antikörper

Bindungsspezifität: C-Term

Sequenz: SDQQAYLVQR GAEDRDWRQQ RNIPIHSCPK CGEVLPDIDT LQIHVMDCII

Homologie: Cow: 92%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 92%

Produktmerkmale: This is a rabbit polyclonal antibody against OPTN. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human OPTN

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 577 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu OPTN

Target: OPTN (Optineurin (OPTN))

Andere Bezeichnung: OPTN

Hintergrund: OPTN is the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.
Alias Symbols: FIP2, GLC1E, HIP7, HYPL, NRP, TFIIIA-INTP, ALS12
Protein Interaction Partner: RAB10, TNIP1, OPTN, DAZAP2, CDC23, UBC, PARK2, ZNF670, ZNF329, TBC1D15, ZNF398, CCDC53, MAP1LC3A, TBC1D17, HACE1, RAB25, RAB11B, SQSTM1, RAB11A, Rab8a, Tfrc, BRE, FAM178A, UQCRQ, GNAS, RAB12, EPS15, RAB14, MAP1LC3B, PIAS4, RNF11, RIPK1, TNFRSF1A, TNF, HTT
Protein Size: 577

Molekulargewicht: 66 kDa

Gen-ID: 10133

NCBI Accession: NM_021980, NP_068815

UniProt: Q96CV9

Pathways: M Phase