GLS2 Antikörper (Middle Region)

Produktnummer ABIN2781319

Zitiert in 2+ Publikationen. Der Kaninchen Polyklonal anti-GLS2 Antikörper (ABIN2781319) detektiert spezifisch GLS2 in WB und IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus, Ratte, Hund, Pferd, Schwein, Zebrafisch (Danio rerio), Rind (Kuh), Meerschweinchen und Kaninchen.

Kurzübersicht für GLS2 Antikörper (Middle Region) (ABIN2781319)

Target: GLS2 (Glutaminase 2 (Liver, Mitochondrial) (GLS2))

Reaktivität: Human, Maus, Ratte, Hund, Pferd, Schwein, Zebrafisch (Danio rerio), Rind (Kuh), Meerschweinchen, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GLS2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-GLS2 Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: GLS2 Antibody - middle region

Sequenz: FVGKEPSGLR YNKLSLNEEG IPHNPMVNAG AIVVSSLIKM DCNKAEKFDF

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against GLS2. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human GLS2

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8101632

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-GLS2 Antikörper (ABIN2781319)

Hu, Lausted, Yoo, Yan, Brightman, Chen, Wang, Bu, Hood: "Quantitative liver-specific protein fingerprint in blood: a signature for hepatotoxicity." in: Theranostics, Vol. 4, Issue 2, pp. 215-28, (2014) (PubMed).

Toriumi, Mouri, Narusawa, Aoyama, Ikawa, Lu, Nagai, Mamiya, Kim, Nabeshima: "Prenatal NMDA receptor antagonism impaired proliferation of neuronal progenitor, leading to fewer glutamatergic neurons in the prefrontal cortex." in: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, Vol. 37, Issue 6, pp. 1387-96, (2012) (PubMed).

Details zu GLS2

Target: GLS2 (Glutaminase 2 (Liver, Mitochondrial) (GLS2))

Andere Bezeichnung: GLS2

Hintergrund:

Background Information: GLS2 is a mitochondrial phosphate-activated glutaminase that catalyzes the hydrolysis of glutamine to stoichiometric amounts of glutamate and ammonia. This protein is functionally similar to the kidney glutaminase but is a little smaller in size. Originally thought to be liver-specific, this protein has been found in other tissues as well.

Gene Name: Glutaminase 2 (liver, mitochondrial)

Alternative Symbols: GA, GLS, LGA, hLGA

Protein Name: Glutaminase liver isoform, mitochondrial

Molekulargewicht: 36kDa

Gen-ID: 27165

UniProt: Q9UI32

Pathways: Dicarboxylic Acid Transport, Warburg Effekt