KDM6A Antikörper (C-Term)

Produktnummer ABIN2781142

Der Kaninchen Polyklonal anti-KDM6A Antikörper (ABIN2781142) detektiert spezifisch KDM6A in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus, Ratte, Hund, Rind (Kuh), Zebrafisch (Danio rerio), Meerschweinchen, Pferd und Kaninchen.

Kurzübersicht für KDM6A Antikörper (C-Term) (ABIN2781142)

Target: KDM6A (Lysine (K)-Specific Demethylase 6A (KDM6A))

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Zebrafisch (Danio rerio), Meerschweinchen, Pferd, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KDM6A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-KDM6A Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: UTX Antibody - C-terminal region

Sequenz: KTYIVHCQDC ARKTSGNLEN FVVLEQYKME DLMQVYDQFT LAPPLPSASS

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against UTX. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of human UTX

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP39483-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu KDM6A

Target: KDM6A (Lysine (K)-Specific Demethylase 6A (KDM6A))

Andere Bezeichnung: UTX

Hintergrund:

Background Information: UTX is a histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. It demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. UTX plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitent with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A.

Gene Name: Lysine (K)-specific demethylase 6A

Alternative Symbols: UTX, KABUK2, bA386N14.2

Protein Name: Lysine-specific demethylase 6A

Molekulargewicht: 154kDa

Gen-ID: 7403

NCBI Accession: NP_066963

UniProt: O15550

Pathways: Tube Formation, Warburg Effekt