KDM6A Antikörper (N-Term)

Produktnummer ABIN2781141

Der Kaninchen Polyklonal anti-KDM6A Antikörper wird verwendet zum Nachweis von KDM6A in Proben von Human, Maus, Ratte, Hund, Rind (Kuh), Zebrafisch (Danio rerio) und Schwein. Er wurde validiert für WB.

Kurzübersicht für KDM6A Antikörper (N-Term) (ABIN2781141)

Target: KDM6A (Lysine (K)-Specific Demethylase 6A (KDM6A))

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Zebrafisch (Danio rerio), Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KDM6A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-KDM6A Antikörper

Bindungsspezifität: N-Term

Sequenz: MKSCGVSLAT AAAAAAAFGD EEKKMAAGKA SGESEEASPS LTAEEREALG

Homologie: Cow: 93%, Dog: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against UTX. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human UTX

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 1401 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu KDM6A

Target: KDM6A (Lysine (K)-Specific Demethylase 6A (KDM6A))

Andere Bezeichnung: UTX

Hintergrund: UTX is a histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. It demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. UTX plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitent with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A.
Alias Symbols: DKFZp686A03225, MGC141941, UTX, bA386N14.2, KABUK2
Protein Interaction Partner: KMT2D, WDR5, ASH2L, RBBP5, SMAD9, HIST2H3C, SRF, SMARCA4, GATA4, NKX2-5, TBX5, UBC, HIST1H3A, WDR82, PAXIP1, NCOA6, TLE1, PROSER1, KMT2C, N4BP2, PPP6R3, ZNF281, HIST3H3,
Protein Size: 1401

Molekulargewicht: 154 kDa

Gen-ID: 7403

NCBI Accession: NM_021140, NP_066963

UniProt: O15550

Pathways: Tube Formation, Warburg Effekt