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PATZ1 Antikörper (Middle Region)

ZNF278 Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Kaninchen, Meerschweinchen, Pferd, Zebrafisch (Danio rerio) WB, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2780923
  • Target Alle PATZ1 (ZNF278) Antikörper anzeigen
    PATZ1 (ZNF278) (Zinc Finger Protein 278 (ZNF278))
    Bindungsspezifität
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reaktivität
    • 22
    • 15
    • 7
    • 5
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Human, Maus, Ratte, Rind (Kuh), Hund, Kaninchen, Meerschweinchen, Pferd, Zebrafisch (Danio rerio)
    Wirt
    • 18
    • 4
    Kaninchen
    Klonalität
    • 20
    • 2
    Polyklonal
    Konjugat
    • 15
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PATZ1 Antikörper ist unkonjugiert
    Applikation
    • 15
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequenz
    SFFRSKSYLN KHIQKVHVRA LGGPLGDLGP ALGSPFSPQQ NMSLLESFGF
    Homologie
    Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 92%
    Produktmerkmale
    This is a rabbit polyclonal antibody against PATZ1. It was validated on Western Blot using a cell lysate as a positive control.
    Aufreinigung
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human PATZ1
    Top Product
    Discover our top product ZNF278 Primärantikörper
  • Applikationshinweise
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 687 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    PATZ1 (ZNF278) (Zinc Finger Protein 278 (ZNF278))
    Andere Bezeichnung
    PATZ1 (ZNF278 Produkte)
    Synonyme
    ZNF278 antikoerper, MAZR antikoerper, PATZ antikoerper, RIAZ antikoerper, ZBTB19 antikoerper, ZSG antikoerper, dJ400N23 antikoerper, 8430401L15Rik antikoerper, AI447519 antikoerper, Mazr antikoerper, Patz antikoerper, Zfp278 antikoerper, Znf278 antikoerper, POZ/BTB and AT hook containing zinc finger 1 antikoerper, POZ/BTB and AT hook containing zinc finger 1 S homeolog antikoerper, POZ (BTB) and AT hook containing zinc finger 1 antikoerper, POZ-, AT hook-, and zinc finger-containing protein 1 antikoerper, PATZ1 antikoerper, patz1.S antikoerper, Patz1 antikoerper, LOC100153931 antikoerper
    Hintergrund
    PATZ1 contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1,22)(p36.1,q12).The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1,22)(p36.1,q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene.
    Alias Symbols: MAZR, PATZ, RIAZ, ZBTB19, ZNF278, ZSG, dJ400N23
    Protein Interaction Partner: TP53, SOX2, PRKAR1A, BCL6, BACH2, RNF4, BACH1, MITF, AR,
    Protein Size: 687
    Molekulargewicht
    74 kDa
    Gen-ID
    23598
    NCBI Accession
    NM_014323, NP_055138
    UniProt
    Q9HBE1
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