PATZ1 Antikörper (N-Term)

Produktnummer ABIN7465764

Produktdetails anti-PATZ1 Antikörper

Target: PATZ1 (ZNF278) (Zinc Finger Protein 278 (ZNF278))

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PATZ1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Kreuzreaktivität: Human

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the N-terminus region of human PATZ1. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Positive Control: HCT116

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.72 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 20 % Glycerol, 0.01 % Thimerosal

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Details zu PATZ1

Target: PATZ1 (ZNF278) (Zinc Finger Protein 278 (ZNF278))

Andere Bezeichnung: POZ/BTB and AT hook containing zinc finger 1 (ZNF278 Produkte)

Synonyme: ZNF278 antikoerper, MAZR antikoerper, PATZ antikoerper, RIAZ antikoerper, ZBTB19 antikoerper, ZSG antikoerper, dJ400N23 antikoerper, 8430401L15Rik antikoerper, AI447519 antikoerper, Mazr antikoerper, Patz antikoerper, Zfp278 antikoerper, Znf278 antikoerper, POZ/BTB and AT hook containing zinc finger 1 antikoerper, POZ/BTB and AT hook containing zinc finger 1 S homeolog antikoerper, POZ (BTB) and AT hook containing zinc finger 1 antikoerper, POZ-, AT hook-, and zinc finger-containing protein 1 antikoerper, PATZ1 antikoerper, patz1.S antikoerper, Patz1 antikoerper, LOC100153931 antikoerper

Hintergrund: POZ/BTB and AT hook containing zinc finger 1 , MAZR , PATZ , RIAZ , ZBTB19 , ZNF278 , ZSG , dJ400N23,The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1,22)(p36.1,q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene. [provided by RefSeq]

Molekulargewicht: 74 kDa

Gen-ID: 23598

UniProt: Q9HBE1