TSG101 Antikörper (C-Term)

Produktnummer ABIN2780762

Dieses Anti-TSG101-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von TSG101 in WB. Geeignet für Human, Maus, Ratte, Hund, Kaninchen, Rind (Kuh), Pferd, Ziege, Meerschweinchen und Zebrafisch (Danio rerio). Dieses Primary Antibody wurde in 1 Publikation zitiert.

Kurzübersicht für TSG101 Antikörper (C-Term) (ABIN2780762)

Target: TSG101 (Tumor Susceptibility Gene 101 (TSG101))

Reaktivität: Human, Maus, Ratte, Hund, Kaninchen, Rind (Kuh), Pferd, Ziege, Meerschweinchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TSG101 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-TSG101 Antikörper

Bindungsspezifität: C-Term

Sequenz: TIFYLGEALR RGVIDLDVFL KHVRLLSRKQ FQLRALMQKA RKTAGLSDLY

Homologie: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against TSG101. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human TSG101

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 390 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-TSG101 Antikörper (ABIN2780762)

Surjit, Oberoi, Kumar, Lal: "Enhanced alpha1 microglobulin secretion from Hepatitis E virus ORF3-expressing human hepatoma cells is mediated by the tumor susceptibility gene 101." in: The Journal of biological chemistry, Vol. 281, Issue 12, pp. 8135-42, (2006) (PubMed).

Details zu TSG101

Target: TSG101 (Tumor Susceptibility Gene 101 (TSG101))

Andere Bezeichnung: TSG101

Hintergrund: TSG101 belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. TSG101 contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. TSG101 may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of TSG101 appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in TSG101 gene occur in high frequency in breast cancer. The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression.
Alias Symbols: TSG10, VPS23
Protein Interaction Partner: USHBP1, CEP55, VPS37C, VPS28, AATF, MGRN1, PDLIM7, TAX1BP1, KRT31, KRT13, KIFC3, DAPK3, AR, FAM9B, VPS37A, HAUS1, SYCE1, UBC, LRSAM1, ADRB2, MVB12A, UBAP1, CDKN1A, HGS, gag, gag-pol, GRB2, CDS2, ZFYVE9, VCP, VPS37B, WDR12, XPO1, UBD, ARRDC1, KCNN4, RAB11F
Protein Size: 390

Molekulargewicht: 44 kDa

Gen-ID: 7251

NCBI Accession: NM_006292, NP_006283

UniProt: Q99816