TIMELESS Antikörper (C-Term)

Produktnummer ABIN2780562

Dieses Anti-TIMELESS-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von TIMELESS in WB. Geeignet für Human, Maus, Ratte, Hund, Rind (Kuh), Pferd, Meerschweinchen, Schaf und Saccharomyces cerevisiae.

Kurzübersicht für TIMELESS Antikörper (C-Term) (ABIN2780562)

Target: TIMELESS (Timeless Homolog (TIMELESS))

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Pferd, Meerschweinchen, Schaf, Saccharomyces cerevisiae

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TIMELESS Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-TIMELESS Antikörper

Bindungsspezifität: C-Term

Sequenz: EEEDAVGKEP LKAAPKKRQL LDSDEEQEED EGRNRAPELG APGIQKKKRY

Homologie: Cow: 100%, Dog: 93%, Guinea Pig: 83%, Horse: 83%, Human: 100%, Mouse: 90%, Rat: 100%, Sheep: 100%, Yeast: 91%

Produktmerkmale: This is a rabbit polyclonal antibody against TIMELESS. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human TIMELESS

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 1208 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu TIMELESS

Target: TIMELESS (Timeless Homolog (TIMELESS))

Andere Bezeichnung: TIMELESS

Hintergrund: The human Timeless protein interacts with both the circadian clock protein cryptochrome 2 and with the cell cycle checkpoint proteins Chk1 and the ATR-ATRIP complex and plays an important role in the DNA damage checkpoint response. Down-regulation of Timeless in human cells seriously compromises replication and intra-S checkpoints, indicating an intimate connection between the circadian cycle and the DNA damage checkpoints that is in part mediated by the Timeless protein.
Alias Symbols: TIM, TIM1, hTIM
Protein Interaction Partner: UBC, TUT1, TF, XRCC1, FKBP3, SP1, SUMO2, Tipin, Timeless, ZSCAN1, PCBD1, CRY1, PER2, PER1, CLSPN, PCNA, per, Clock, ATRIP, CRY2, CHEK1,
Protein Size: 1208

Molekulargewicht: 139 kDa

Gen-ID: 8914

NCBI Accession: NM_003920, NP_003911

UniProt: Q9UNS1

Pathways: Protein targeting to Nucleus, Photoperiodism