MNDA Antikörper (C-Term)

Produktnummer ABIN405140

Der Kaninchen Polyklonal Anti-MNDA-Antikörper wurde für WB validiert. Er ist geeignet, MNDA in Proben von Human zu detektieren.

Kurzübersicht für MNDA Antikörper (C-Term) (ABIN405140)

Target: MNDA (Myeloid Cell Nuclear Differentiation Antigen (MNDA))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MNDA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-MNDA Antikörper

Bindungsspezifität: C-Term

Sequenz: KCEKGDKLRL FCLQLRTVDR KLKLVCGSHS FIKVIKAKKN KEGPMNVN

Homologie: Human: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against MNDA. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human MNDA

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 407 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu MNDA

Target: MNDA (Myeloid Cell Nuclear Differentiation Antigen (MNDA))

Andere Bezeichnung: MNDA

Hintergrund: The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage.MNDA may act as a transcriptional activator/repressor in the myeloid lineage. It plays a role in the granulocyte/monocyte cell-specific response to interferon. MNDA stimulates the DNA binding of the transcriptional repressor protein YY1.The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: PYHIN3
Protein Interaction Partner: PRMT6, WHSC1L1, PRMT7, TP53, RBL2, RB1, HOXB2, CDK2, CDK1,
Protein Size: 407

Molekulargewicht: 46 kDa

Gen-ID: 4332

NCBI Accession: NM_002432, NP_002423

UniProt: P41218