ATF4 Antikörper (C-Term)

Produktnummer ABIN2780378

Der Kaninchen Polyklonal anti-ATF4 Antikörper wird verwendet zum Nachweis von ATF4 in Proben von Human, Maus, Ratte, Hund, Rind (Kuh), Meerschweinchen, Schaf, Pferd und Saccharomyces cerevisiae. Er wurde validiert für WB.

Kurzübersicht für ATF4 Antikörper (C-Term) (ABIN2780378)

Target: ATF4 (Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4))

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Meerschweinchen, Schaf, Pferd, Saccharomyces cerevisiae

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ATF4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-ATF4 Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: ATF4 Antibody - C-terminal region

Sequenz: EQNKTAATRY RQKKRAEQEA LTGECKELEK KNEALKERAD SLAKEIQYLK

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Rat: 93%, Sheep: 93%, Yeast: 82%

Produktmerkmale: This is a rabbit polyclonal antibody against ATF4. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human ATF4

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP38067-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu ATF4

Target: ATF4 (Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4))

Andere Bezeichnung: ATF4

Hintergrund:

Background Information: ATF4s a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromsome at q28 in a region containing a large inverted duplication.

Gene Name: Activating transcription factor 4 (tax-responsive enhancer element B67)

Alternative Symbols: CREB2, TXREB, CREB-2, TAXREB67

Protein Name: Cyclic AMP-dependent transcription factor ATF-4

Molekulargewicht: 39kDa

Gen-ID: 468

NCBI Accession: NP_001666

UniProt: P18848

Pathways: Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, ER-Nucleus Signaling, Unfolded Protein Response