MITF Antikörper (Middle Region)

Produktnummer ABIN2780334

This anti-MITF antibody (ABIN2780334) is a Rabbit Polyclonal antibody detecting MITF in WB. Suitable for Human, Mouse, Rat, Dog, Rabbit, Horse, Guinea Pig, Cow, Sheep, Zebrafish (Danio rerio), Goat.

Kurzübersicht für MITF Antikörper (Middle Region) (ABIN2780334)

Target: MITF (Microphthalmia-Associated Transcription Factor (MITF))

Reaktivität: Human, Maus, Ratte, Hund, Kaninchen, Pferd, Meerschweinchen, Rind (Kuh), Schaf, Zebrafisch (Danio rerio), Ziege

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MITF Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-MITF Antikörper

Bindungsspezifität: Middle Region

Sequenz: MGSKLEDILM DDTLSPVGVT DPLLSSVSPG ASKTSSRRSS MSMEETEHTC

Homologie: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against MITF. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human MITF

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 419 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-MITF Antikörper (ABIN2780334)

Ursini, Cavalleri, Fazio, Angrisano, Iacovelli, Porcelli, Maddalena, Punzi, Mancini, Gelao, Romano, Masellis, Calabrese, Rampino, Taurisano, Di Giorgio, Keller, Tarantini, Sinibaldi, Quarto et al.: "BDNF rs6265 methylation and genotype interact on risk for schizophrenia. ..." in: Epigenetics, Vol. 11, Issue 1, pp. 11-23, (2016) (PubMed).

Details zu MITF

Target: MITF (Microphthalmia-Associated Transcription Factor (MITF))

Andere Bezeichnung: MITF

Hintergrund: MITF is a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene encodes a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
Alias Symbols: WS2A, MI, WS2, bHLHe32
Protein Interaction Partner: EBP, STUB1, HK3, EPAS1, LEF1, APP, HINT1, ELAVL1, CDK2, SUMO2, PSMD14, MARK3, PIAS3, PIAS2, PIAS1, SUMO1, UBE2I, PAX3, OTX2, PAX6, PATZ1, GSK3B, TFEC, EP300, RPS6KA1, TFEB, MAPK14, TFE3, MAPK1, SPI1, FOS, CTNNB1, CDKN1A, RB1,
Protein Size: 419

Molekulargewicht: 47 kDa

Gen-ID: 4286

NCBI Accession: NM_000248, NP_000239

Pathways: Chromatin Binding