MITF Antikörper (Middle Region)
Kurzübersicht für MITF Antikörper (Middle Region) (ABIN2780334)
Target
Alle MITF Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
- 
    - 
                                            Bindungsspezifität
- Middle Region
- 
                                            Sequenz
- MGSKLEDILM DDTLSPVGVT DPLLSSVSPG ASKTSSRRSS MSMEETEHTC
- 
                                            Homologie
- Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 100%
- 
                                            Produktmerkmale
- This is a rabbit polyclonal antibody against MITF. It was validated on Western Blot using a cell lysate as a positive control.
- 
                                            Aufreinigung
- Affinity Purified
- 
                                            Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human MITF
 
- 
                                            
- 
    
- 
    - 
                                            Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- 
                                            Kommentare
- 
                        Antigen size: 419 AA 
- 
                                            Beschränkungen
- Nur für Forschungszwecke einsetzbar
 
- 
                                            
- 
    - 
                                            Format
- Liquid
- 
                                            Konzentration
- Lot specific
- 
                                            Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 
                                            Konservierungsmittel
- Sodium azide
- 
                                            Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 
                                            Handhabung
- Avoid repeated freeze-thaw cycles.
- 
                                            Lagerung
- -20 °C
- 
                                            Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
 
- 
                                            
- 
    - 
                                            : "BDNF rs6265 methylation and genotype interact on risk for schizophrenia. ..."    in: Epigenetics, Vol. 11, Issue 1, pp. 11-23, (2016)         (PubMed).        
 
 
- 
                                            : "BDNF rs6265 methylation and genotype interact on risk for schizophrenia. ..."    in: Epigenetics, Vol. 11, Issue 1, pp. 11-23, (2016)         (PubMed).        
- 
    - MITF (Microphthalmia-Associated Transcription Factor (MITF))
- 
                                            Andere Bezeichnung
- MITF
- 
                                            Hintergrund
- 
                        MITF is a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene encodes a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
 Alias Symbols: WS2A, MI, WS2, bHLHe32
 Protein Interaction Partner: EBP, STUB1, HK3, EPAS1, LEF1, APP, HINT1, ELAVL1, CDK2, SUMO2, PSMD14, MARK3, PIAS3, PIAS2, PIAS1, SUMO1, UBE2I, PAX3, OTX2, PAX6, PATZ1, GSK3B, TFEC, EP300, RPS6KA1, TFEB, MAPK14, TFE3, MAPK1, SPI1, FOS, CTNNB1, CDKN1A, RB1,
 Protein Size: 419
- 
                                            Molekulargewicht
- 47 kDa
- 
                                            Gen-ID
- 4286
- 
                                            NCBI Accession
- NM_000248, NP_000239
- 
                                            Pathways
- Chromatin Binding
 Target
- 
                    
 
                                     
                                     
                                    