PITX2 Antikörper (Paired-Like Homeodomain 2) (N-Term)

Details for Product anti-PITX2 Antibody No. ABIN2779638, Anbieter: Anmelden zum Anzeigen
Antigen
  • ARP1
  • Brx1
  • IDG2
  • IGDS
  • IGDS2
  • IHG2
  • IRID2
  • Otlx2
  • PTX2
  • RGS
  • RIEG
  • RIEG1
  • RS
  • 9430085M16Rik
  • Brx1a
  • Brx1b
  • Munc30
  • Pitx2a
  • Pitx2b
  • Pitx2c
  • Pitx2cbeta
  • Ptx2
  • Rieg
  • pitx2a
  • pitx2c
  • zgc:110508
  • XPtx2b
  • xPtx2
  • xpitx2
  • arp1
  • brx1
  • idg2
  • igds
  • igds2
  • ihg2
  • irid2
  • otlx2
  • pitx2-A
  • ptx2
  • rgs
  • rieg
  • rieg1
  • pitx-2
  • pitx2
  • paired like homeodomain 2
  • paired-like homeodomain transcription factor 2
  • paired-like homeodomain 2
  • paired like homeodomain 2 S homeolog
  • paired like homeodomain 2 L homeolog
  • PITX2
  • Pitx2
  • pitx2
  • pitx2.S
  • pitx2.L
Epitop
N-Term
16
12
12
10
7
4
4
4
2
1
1
1
1
1
1
Reaktivität
Pferd, Human, Maus
81
17
17
4
3
3
3
3
2
2
1
1
1
1
1
Wirt
Kaninchen
75
6
1
Klonalität
Polyklonal
Konjugat
Dieser PITX2 Antikörper ist unkonjugiert
5
5
5
4
4
4
Applikation
Western Blotting (WB)
70
52
10
9
2
2
1
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human PITX2
Blocking Peptide Zu diesem Produkt passt das Blocking Peptide ABIN981798.
Sequenz EFTDSPESRK EAASSKFFPR QHPGANEKDK SQQGKNEDVG AEDPSKKKRQ
Homologie Horse: 86%, Human: 100%, Mouse: 93%
Produktmerkmale This is a rabbit polyclonal antibody against PITX2. It was validated on Western Blot using a cell lysate as a positive control.
Reinigung Affinity Purified
Plasmids, Primers & others Plasmide, Primers & weitere PITX2 products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung PITX2 (PITX2 Antibody Abstract)
Hintergrund The PITX2 gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. This protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. Mutations in PITX2 are associated with Axenfeld-Rieger syndrome (ARS), iridogoniodysgenesis syndrome (IGDS), and sporadic cases of Peters anomaly. This protein is involved in the development of the eye, tooth and abdominal organs. It also acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described.
Alias Symbols: ARP1, Brx1, IDG2, IGDS, IGDS2, IHG2, IRID2, MGC111022, MGC20144, Otlx2, PTX2, RGS, RIEG, RIEG1, RS
Protein Interaction Partner: LEF1, Hoxa1, WDR5, SMAD3, HDAC1, CTNNB1, ZNHIT3, TRIM25, HERC5, PDLIM1, PITX2, PROP1, KAT5, Pou1f1, MSX2,
Protein Size: 317
Molekulargewicht 35 kDa
Gen-ID 5308
NCBI Accession NM_153426, NP_700475
UniProt Q99697
Pathways Retinoic Acid Receptor Signaling Pathway, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
Applikations-hinweise Optimal working dilutions should be determined experimentally by the investigator.
Kommentare

Antigen size: 317 AA

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Bilder des Herstellers
Western Blotting (WB) image for anti-Paired-Like Homeodomain 2 (PITX2) (N-Term) antibody (ABIN2779638) WB Suggested Anti-PITX2 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:31250 Posi...
Western Blotting (WB) image for anti-Paired-Like Homeodomain 2 (PITX2) (N-Term) antibody (ABIN2779638) Host: Mouse Target Name: PITX2 Sample Tissue: Mouse Brain Antibody Dilution: 1...
Produkt verwendet in: Holmberg, Ingner, Johansson, Leander, Hjalt: "PITX2 gain-of-function induced defects in mouse forelimb development." in: BMC developmental biology, Vol. 8, pp. 25, 2008 (PubMed).

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