DVL1 Antikörper (C-Term)

Produktnummer ABIN2779457

Dieses Anti-DVL1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von DVL1 in WB. Geeignet für Human, Maus, Ratte, Schwein, Rind (Kuh), Hund, Meerschweinchen, Pferd und Saccharomyces cerevisiae.

Kurzübersicht für DVL1 Antikörper (C-Term) (ABIN2779457)

Target: DVL1 (Dishevelled Segment Polarity Protein 1 (DVL1))

Reaktivität: Human, Maus, Ratte, Schwein, Rind (Kuh), Hund, Meerschweinchen, Pferd, Saccharomyces cerevisiae

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DVL1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-DVL1 Antikörper

Bindungsspezifität: C-Term

Sequenz: AAGAGGSGSE SDHTAPSGVG SSWRERPAGQ LSRGSSPRSQ ASATAPGLPP

Homologie: Cow: 86%, Dog: 86%, Guinea Pig: 79%, Horse: 86%, Human: 100%, Mouse: 86%, Pig: 93%, Rat: 86%, Yeast: 85%

Produktmerkmale: This is a rabbit polyclonal antibody against DVL1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human DVL1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 670 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu DVL1

Target: DVL1 (Dishevelled Segment Polarity Protein 1 (DVL1))

Andere Bezeichnung: DVL1

Hintergrund: DVL1 is a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 gene is a candidate for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1 gene. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development.DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development. Three transcript variants encoding three different isoforms have been found for this gene.
Alias Symbols: DVL, MGC54245, DVL1L1
Protein Interaction Partner: NCK2, TRIM69, NUMA1, HUWE1, UBC, DVL2, WWOX, SIPA1, PSMA3, LRRK2, ITCH, HECW1, NEDD4, ANXA7, SDC4, NKD2, CYLD, SIRT1, CCDC88C, VANGL1, CXXC4, PPM1A, DYNLT1, HDHD2, BRD7, DAAM1, AXIN1, USP13, SMAD3, SMAD7, FRAT1, RAC1, DVL3, SMAD2, DVL1, SMAD4, CSNK1D, CSN
Protein Size: 670

Molekulargewicht: 73 kDa

Gen-ID: 1855

NCBI Accession: NM_004421, NP_004412

Pathways: WNT Signalweg, Synaptic Membrane, Skeletal Muscle Fiber Development