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NK2 Homeobox 5 Antikörper (N-Term)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch NK2 Homeobox 5 in WB. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Kaninchen und Pferd.
Produktnummer ABIN2779388

Kurzübersicht für NK2 Homeobox 5 Antikörper (N-Term) (ABIN2779388)

Target

Alle NK2 Homeobox 5 (NKX2-5) Antikörper anzeigen
NK2 Homeobox 5 (NKX2-5)

Reaktivität

  • 41
  • 19
  • 6
  • 5
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Kaninchen, Pferd

Wirt

  • 42
  • 8
  • 1
Kaninchen

Klonalität

  • 44
  • 7
Polyklonal

Konjugat

  • 41
  • 3
  • 2
  • 2
  • 2
  • 1
Dieser NK2 Homeobox 5 Antikörper ist unkonjugiert

Applikation

  • 43
  • 29
  • 8
  • 6
  • 6
  • 4
  • 3
  • 2
  • 1
  • 1
Western Blotting (WB)
  • Bindungsspezifität

    • 7
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term

    Sequenz

    ELGRAPSPAK CASAFPAAPA FYPRAYSDPD PAKDPRAEKK ELCALQKAVE

    Homologie

    Cow: 85%, Dog: 85%, Guinea Pig: 92%, Horse: 77%, Human: 100%, Mouse: 92%, Rabbit: 77%, Rat: 92%

    Produktmerkmale

    This is a rabbit polyclonal antibody against NKX2-5. It was validated on Western Blot using a cell lysate as a positive control.

    Aufreinigung

    Affinity Purified

    Immunogen

    The immunogen is a synthetic peptide directed towards the n terminal region of human Nkx2-5
  • Applikationshinweise

    Optimal working dilutions should be determined experimentally by the investigator.

    Kommentare

    Antigen size: 324 AA

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    Lot specific

    Buffer

    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freeze-thaw cycles.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target

    NK2 Homeobox 5 (NKX2-5)

    Andere Bezeichnung

    Nkx2-5

    Hintergrund

    Homeobox-containing genes play critical roles in regulating tissue-specific gene expression essential for tissue differentiation, as well as determining the temporal and spatial patterns of development. It has been demonstrated that a Drosophila homeobox-containing gene called 'tinman' is expressed in the developing dorsal vessel and in the equivalent of the vertebrate heart. Mutations in tinman result in loss of heart formation in the embryo, suggesting that tinman is essential for Drosophila heart formation. Furthermore, abundant expression of Csx, the presumptive mouse homolog of tinman, is observed only in the heart from the time of cardiac differentiation. CSX, the human homolog of murine Csx, has a homeodomain sequence identical to that of Csx and is expressed only in the heart, again suggesting that CSX plays an important role in human heart formation.Homeobox-containing genes play critical roles in regulating tissue-specific gene expression essential for tissue differentiation, as well as determining the temporal and spatial patterns of development (Shiojima et al., 1995 [PubMed 7665173]). It has been demonstrated that a Drosophila homeobox-containing gene called 'tinman' is expressed in the developing dorsal vessel and in the equivalent of the vertebrate heart. Mutations in tinman result in loss of heart formation in the embryo, suggesting that tinman is essential for Drosophila heart formation. Furthermore, abundant expression of Csx, the presumptive mouse homolog of tinman, is observed only in the heart from the time of cardiac differentiation. CSX, the human homolog of murine Csx, has a homeodomain sequence identical to that of Csx and is expressed only in the heart, again suggesting that CSX plays an important role in human heart formation.[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-1211 U34962.1 1-1211 1212-1585 BC025711.1 1143-1516
    Alias Symbols: CSX, CSX1, NKX2.5, NKX2E, NKX4-1, VSD3, CHNG5, HLHS2
    Protein Interaction Partner: JARID2, GATA4, KDM6A, SMAD4, CAMTA2, TLE1, HDAC1, ID3, ID2, ID1, HIPK1, HIPK2, FOXH1, TBX5, TBX2, SRF, CSNK2A1,
    Protein Size: 324

    Molekulargewicht

    35 kDa

    Gen-ID

    1482

    NCBI Accession

    NM_004387, NP_004378

    UniProt

    P52952

    Pathways

    Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
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