BCL2L1 Antikörper (N-Term)

Produktnummer ABIN2779336

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch BCL2L1 in WB. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte, Schwein, Schaf, Hund, Rind (Kuh), Kaninchen, Pferd und Meerschweinchen.

Kurzübersicht für BCL2L1 Antikörper (N-Term) (ABIN2779336)

Target: BCL2L1 (BCL2-Like 1 (BCL2L1))

Reaktivität: Human, Maus, Ratte, Schwein, Schaf, Hund, Rind (Kuh), Kaninchen, Pferd, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BCL2L1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-BCL2L1 Antikörper

Bindungsspezifität: N-Term

Sequenz: SNRELVVDFL SYKLSQKGYS WSQFSDVEEN RTEAPEGTES EMETPSAING

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 92%, Pig: 100%, Rabbit: 100%, Rat: 93%, Sheep: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against BCL2L1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human BCL2L1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 233 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu BCL2L1

Target: BCL2L1 (BCL2-Like 1 (BCL2L1))

Andere Bezeichnung: BCL2L1

Hintergrund: BCL2L1 encodes a protein which belongs to the BCL-2 protein family. The proteins encoded by BCL2L1 are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis.The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator.
Alias Symbols: BCL-XL/S, BCL2L, BCLX, Bcl-X, DKFZp781P2092, bcl-xL, bcl-xS, BCLXL, BCLXS, PPP1R52
Protein Interaction Partner: BCL2L1, BCL2, BAX, BAD, BMF, BBC3, CASP8AP2, BECN1, UBC, TPT1, TP53BP2, ced-9, ced-4, PGAM5, CDKN2A, CASP1, BCL2L11, HRK, PMAIP1, BIK, BID, PARK2, PINK1, BAK1, RAD9A, AKT1, Mapk1, ATXN3, CLU, BCAP31, CRYAB, CRYAA, BFAR, PPP1CC, PPP1CA, ACTB, UBR1, METTL23
Protein Size: 233

Molekulargewicht: 26 kDa

Gen-ID: 598

NCBI Accession: NM_138578, NP_612815

UniProt: Q07817

Pathways: Apoptose, Negative Regulation of intrinsic apoptotic Signaling