Amphiregulin Antikörper (Middle Region)

Produktnummer ABIN2779308

Produktdetails anti-Amphiregulin Antikörper

Target: Amphiregulin (AREG)

Bindungsspezifität: Middle Region

Reaktivität: Human, Rind (Kuh), Hund, Pferd, Schwein, Schaf

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Amphiregulin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: PQIPGYIVDD SVRVEQVVKP PQNKTESENT SDKPKRKKKG GKNGKNRRNR

Homologie: Cow: 91%, Dog: 91%, Horse: 91%, Human: 100%, Pig: 91%, Sheep: 91%

Produktmerkmale: This is a rabbit polyclonal antibody against AREG. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human AREG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 252 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu Amphiregulin

Target: Amphiregulin (AREG)

Andere Bezeichnung: AREG (AREG Produkte)

Hintergrund: The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells, and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). This protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. This encoded protein is associated with a psoriasis-like skin phenotype.
Alias Symbols: AR, AREGB, CRDGF, MGC13647, SDGF
Protein Interaction Partner: KRTAP10-3, WDR92, UBC, APP, UBQLN4, WT1, EGFR, CCND3, MMP9,
Protein Size: 252

Molekulargewicht: 28 kDa

Gen-ID: 374

NCBI Accession: NM_001657, NP_001648

UniProt: P15514

Pathways: RTK Signalweg, EGFR Signaling Pathway