SKP2 Antikörper (C-Term)

Produktnummer ABIN2779304

Der Kaninchen Polyklonal anti-SKP2 Antikörper wird verwendet zum Nachweis von SKP2 in Proben von Human, Ratte, Rind (Kuh), Schwein, Pferd, Hund, Meerschweinchen und Kaninchen. Er wurde validiert für WB.

Kurzübersicht für SKP2 Antikörper (C-Term) (ABIN2779304)

Target: SKP2 (S-Phase Kinase-Associated Protein 2 (SKP2))

Reaktivität: Human, Ratte, Rind (Kuh), Schwein, Pferd, Hund, Meerschweinchen, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SKP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-SKP2 Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: SKP2 Antibody - C-terminal region

Sequenz: TLQLLKEALP HLQINCSHFT TIARPTIGNK KNQEIWGIKC RLTLQKPSCL

Homologie: Cow: 100%, Dog: 92%, Guinea Pig: 83%, Horse: 92%, Human: 100%, Pig: 100%, Rabbit: 100%, Rat: 75%

Produktmerkmale: This is a rabbit polyclonal antibody against SKP2. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human SKP2

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP30219-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu SKP2

Target: SKP2 (S-Phase Kinase-Associated Protein 2 (SKP2))

Andere Bezeichnung: SKP2

Hintergrund:

Background Information: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class, in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas.

Gene Name: S-phase kinase-associated protein 2, E3 ubiquitin protein ligase

Alternative Symbols: p45, FBL1, FLB1, FBXL1

Protein Name: S-phase kinase-associated protein 2

Molekulargewicht: 23kDa

Gen-ID: 6502

UniProt: Q13309

Pathways: Mitotic G1-G1/S Phases