STAU1/Staufen Antikörper (N-Term)

Produktnummer ABIN2779109

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch STAU1/Staufen in WB und IHC. Es zeigt Reaktivität gegenüber Proben von Human, Ratte, Pferd, Rind (Kuh), Meerschweinchen, Hund und Kaninchen.

Kurzübersicht für STAU1/Staufen Antikörper (N-Term) (ABIN2779109)

Target: STAU1/Staufen (STAU1) (Staufen Double-Stranded RNA Binding Protein 1 (STAU1))

Reaktivität: Human, Ratte, Pferd, Rind (Kuh), Meerschweinchen, Hund, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser STAU1/Staufen Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-STAU1/Staufen Antikörper

Bindungsspezifität: N-Term

Sequenz: SQVQVQVQNP SAALSGSQIL NKNQSLLSQP LMSIPSTTSS LPSENAGRPI

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against STAU1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human STAU1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 577 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu STAU1/Staufen

Target: STAU1/Staufen (STAU1) (Staufen Double-Stranded RNA Binding Protein 1 (STAU1))

Andere Bezeichnung: STAU1

Hintergrund: This protein is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are haracterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translationStaufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. Five transcript variants resulting from alternative splicing of STAU gene and encoding three isoforms have been described. Three of these variants encode the same isoform, however, differ in their 5'UTR.
Alias Symbols: FLJ25010, STAU
Protein Interaction Partner: LONRF1, GLRX3, ZMAT3, NXT1, SPRTN, MATR3, EIF4A3, NUP155, PRDX6, NPEPPS, DDX23, DDX21, AIFM1, INA, ATP6V0D1, SART1, RPL14, AP3D1, CPNE3, IQGAP1, PABPC4, EIF3D, EIF3B, EIF3A, PRKRA, KHSRP, IRS4, SLC25A11, SMC1A, PABPN1, DDX39B, TUBA1A, MOGS, YWHAZ, XPO1, V
Protein Size: 577

Molekulargewicht: 63 kDa

Gen-ID: 6780

NCBI Accession: NM_017453, NP_059347

UniProt: O95793

Pathways: Asymmetric Protein Localization