SRSF1 Antikörper (Middle Region)

Produktnummer ABIN2779014

Der Kaninchen Polyklonal anti-SRSF1 Antikörper wird verwendet zum Nachweis von SRSF1 in Proben von Human, Maus, Ratte, Zebrafisch (Danio rerio), Hund, Meerschweinchen, Rind (Kuh), Pferd und Kaninchen. Er wurde validiert für WB.

Kurzübersicht für SRSF1 Antikörper (Middle Region) (ABIN2779014)

Target: SRSF1 (serine/arginine-Rich Splicing Factor 1 (SRSF1))

Reaktivität: Human, Maus, Ratte, Zebrafisch (Danio rerio), Hund, Meerschweinchen, Rind (Kuh), Pferd, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SRSF1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-SRSF1 Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: SFRS1 Antibody - middle region

Sequenz: GVVEFVRKED MTYAVRKLDN TKFRSHEGET AYIRVKVDGP RSPSYGRSRS

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against SFRS1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SFRS1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP40692-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu SRSF1

Target: SRSF1 (serine/arginine-Rich Splicing Factor 1 (SRSF1))

Andere Bezeichnung: SFRS1

Hintergrund:

Background Information: SFRS1 is a member of the arginine/serine-rich splicing factor protein family, and functions in both constitutive and alternative pre-mRNA splicing. The protein binds to pre-mRNA transcripts and components of the spliceosome, and can either activate or repress splicing depending on the location of the pre-mRNA binding site. The protein's ability to activate splicing is regulated by phosphorylation and interactions with other splicing factor associated proteins. Multiple transcript variants encoding different isoforms have been found for this gene.Alternative mRNA splicing plays an important role in development and differentiation, many transcripts are spliced differently in distinct cell types and tissues. Both constitutive and alternative splicing occurs on spliceosomes, which are complex particles composed of small nuclear ribonucleoproteins (snRNPs) and non-snRNP proteins. The SR family of non-snRNP splicing factors is characterized by the presence of an RNA recognition motif and a serine- and arginine-rich (SR) domain. SR proteins are required at early stages of spliceosome assembly, have distinct but overlapping specificities for different pre-mRNAs, and can alter splice site choice, suggesting that they may be involved in the regulation of alternative splicing in vivo. Two of the SR proteins, ASF/SF2 (SFRS1) and SC35 (SFRS2, MIM 600813), have been extensively characterized (Bermingham et al., 1995).[supplied by OMIM].

Gene Name: Serine/arginine-rich splicing factor 1

Alternative Symbols: ASF, SF2, SFRS1, SF2p33, SRp30a

Protein Name: Serine/arginine-rich splicing factor 1

Molekulargewicht: 27kDa

Gen-ID: 6426

NCBI Accession: NP_008855

UniProt: Q07955

Pathways: Ribonucleoprotein Complex Subunit Organization