NXF1 Antikörper (N-Term)

Produktnummer ABIN2778977

Der Kaninchen Polyklonal anti-NXF1 Antikörper (ABIN2778977) detektiert spezifisch NXF1 in WB und IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Ratte, Maus, Hund, Meerschweinchen und Rind (Kuh).

Kurzübersicht für NXF1 Antikörper (N-Term) (ABIN2778977)

Target: NXF1 (Nuclear RNA Export Factor 1 (NXF1))

Reaktivität: Human, Ratte, Maus, Hund, Meerschweinchen, Rind (Kuh)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NXF1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-NXF1 Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: NXF1 Antibody - N-terminal region

Sequenz: MADEGKSYSE HDDERVNFPQ RKKKGRGPFR WKYGEGNRRS GRGGSGIRSS

Homologie: Cow: 92%, Dog: 83%, Guinea Pig: 92%, Human: 100%, Mouse: 92%, Rat: 92%

Produktmerkmale: This is a rabbit polyclonal antibody against NXF1. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human NXF1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP40639-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu NXF1

Target: NXF1 (Nuclear RNA Export Factor 1 (NXF1))

Andere Bezeichnung: NXF1

Hintergrund:

Background Information: NXF1 is one member of a family of nuclear RNA export factor. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. NXF1 shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. NXF1 overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses.This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses.

Gene Name: Nuclear RNA export factor 1

Alternative Symbols: TAP, MEX67

Protein Name: Nuclear RNA export factor 1

Molekulargewicht: 68kDa

Gen-ID: 10482

NCBI Accession: NP_006353

UniProt: Q9UBU9