SNRNP70 Antikörper (N-Term)

Produktnummer ABIN183913

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch SNRNP70 in WB und IHC. Es zeigt Reaktivität gegenüber Proben von Human, Ratte, Maus, Hund, Zebrafisch (Danio rerio), Rind (Kuh), Meerschweinchen, Kaninchen und Pferd. Es wurde in 2+ Publikationen zitiert.

Kurzübersicht für SNRNP70 Antikörper (N-Term) (ABIN183913)

Target: SNRNP70 (Small Nuclear Ribonucleoprotein 70kDa (U1) (SNRNP70))

Reaktivität: Human, Ratte, Maus, Hund, Zebrafisch (Danio rerio), Rind (Kuh), Meerschweinchen, Kaninchen, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SNRNP70 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-SNRNP70 Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: SNRP70 Antibody - N-terminal region

Sequenz: PHNDPNAQGD AFKTLFVARV NYDTTESKLR REFEVYGPIK RIHMVYSKRS

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against SNRP70. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SNRP70

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8111920

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-SNRNP70 Antikörper (ABIN183913)

Wang, Mueller, Hertel, Cambi: "G Run-mediated recognition of proteolipid protein and DM20 5' splice sites by U1 small nuclear RNA is regulated by context and proximity to the splice site." in: The Journal of biological chemistry, Vol. 286, Issue 6, pp. 4059-71, (2011) (PubMed).

Wang, Cambi: "Heterogeneous nuclear ribonucleoproteins H and F regulate the proteolipid protein/DM20 ratio by recruiting U1 small nuclear ribonucleoprotein through a complex array of G runs." in: The Journal of biological chemistry, Vol. 284, Issue 17, pp. 11194-204, (2009) (PubMed).

Details zu SNRNP70

Target: SNRNP70 (Small Nuclear Ribonucleoprotein 70kDa (U1) (SNRNP70))

Andere Bezeichnung: SNRP70

Hintergrund:

Background Information: SNRP70 contains 1 RRM (RNA recognition motif) domain and mediates the splicing of pre-mRNA by binding to the loop I region of U1-snRNA. Western blots using two different antibodies against two unique regions of this protein target confirm the same apparent molecular weight in our tests.

Gene Name: Small nuclear ribonucleoprotein 70 kDa (U1)

Alternative Symbols: RPU1, Snp1, U1AP, U170K, U1RNP, RNPU1Z, SNRP70, U1-70K

Protein Name: U1 small nuclear ribonucleoprotein 70 kDa

Molekulargewicht: 52kDa

Gen-ID: 6625

NCBI Accession: NP_003080

UniProt: P08621