PARP16 Antikörper (Middle Region)

Produktnummer ABIN2778107

Der Kaninchen Polyklonal Anti-PARP16-Antikörper wurde für WB und IHC validiert. Er ist geeignet, PARP16 in Proben von Human, Maus, Ratte, Meerschweinchen, Pferd, Rind (Kuh), Hund, Schwein und Kaninchen zu detektieren. Es ist 1 Publikation verfügbar.

Kurzübersicht für PARP16 Antikörper (Middle Region) (ABIN2778107)

Target: PARP16 (Poly (ADP-Ribose) Polymerase Family, Member 16 (PARP16))

Reaktivität: Human, Maus, Ratte, Meerschweinchen, Pferd, Rind (Kuh), Hund, Schwein, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PARP16 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-PARP16 Antikörper

Bindungsspezifität: Middle Region

Sequenz: PKYFVVTNNQ LLRVKYLLVY SQKPPKSRAS SQLSWFSSHW FTVMISLYLL

Homologie: Cow: 79%, Dog: 86%, Guinea Pig: 79%, Horse: 86%, Human: 100%, Mouse: 86%, Pig: 80%, Rabbit: 86%, Rat: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against PARP16. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PARP16

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 323 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-PARP16 Antikörper (ABIN2778107)

Di Paola, Micaroni, Di Tullio, Buccione, Di Girolamo: "PARP16/ARTD15 is a novel endoplasmic-reticulum-associated mono-ADP-ribosyltransferase that interacts with, and modifies karyopherin-ß1." in: PLoS ONE, Vol. 7, Issue 6, pp. e37352, (2012) (PubMed).

Details zu PARP16

Target: PARP16 (Poly (ADP-Ribose) Polymerase Family, Member 16 (PARP16))

Andere Bezeichnung: PARP16

Hintergrund: Poly(ADP-ribosyl)ation is an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. PARP16 is a member of poly(ADP-ribose) polymerases (PARPs) family that is encoded by different genes and displaying a conserved catalytic domain in which PARP-1 (113 kDa), the founding member, and PARP-2 (62 kDa) are so far the sole enzymes whose catalytic activity has been shown to be immediately stimulated by DNA strand breaks. A large repertoire of sequences encoding novel PARPs now extends considerably the field of poly(ADP-ribosyl)ation reactions to various aspects of the cell biology including cell proliferation and cell death. Some of these new members interact with each other, share common partners and common subcellular localizations suggesting possible fine tuning in the regulation of this post-translational modification of proteins.
Alias Symbols: C15orf30, FLJ20509, FLJ25281, pART15
Protein Interaction Partner: GMCL1, UBC, NEDD4,
Protein Size: 323

Molekulargewicht: 36 kDa

Gen-ID: 54956

NCBI Accession: NM_017851, NP_060321