SOX5 Antikörper (C-Term)

Produktnummer ABIN2777862

Dieser Anti-SOX5 Antikörper ist ein Kaninchen Polyklonal Antikörper zur Detektion von SOX5 in WB. Geeignet für Human, Ratte, Maus, Meerschweinchen, Pferd, Kaninchen, Rind (Kuh) und Hund. Dieses Primary Antibody wurde in 12+ Publikationen zitiert.

Kurzübersicht für SOX5 Antikörper (C-Term) (ABIN2777862)

Target: SOX5 (SRY (Sex Determining Region Y)-Box 5 (SOX5))

Reaktivität: Human, Ratte, Maus, Meerschweinchen, Pferd, Kaninchen, Rind (Kuh), Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SOX5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-SOX5 Antikörper

Bindungsspezifität: C-Term

Sequenz: PEPGMPVIQS TYGVKGEEPH IKEEIQAEDI NGEIYDEYDE EEDDPDVDYG

Spezifität: Designed to recognize all five isoforms of human SOX5 (84, 82, 42, 71 and 83 kDa)

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 92%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against SOX5. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human SOX5

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 377 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-SOX5 Antikörper (ABIN2777862)

Zhang, Liu, Li, Zhang, Li, Liu, Min, Shuang, Song, Zhang: "Transcriptional regulation of human sperm-associated antigen 16 gene by S-SOX5." in: BMC molecular biology, Vol. 18, Issue 1, pp. 2, (2017) (PubMed).

Naveau, Pinson, Gérard, Nguyen, Charlier, Thomé, Zoeller, Bourguignon, Parent: "Alteration of rat fetal cerebral cortex development after prenatal exposure to polychlorinated biphenyls." in: PLoS ONE, Vol. 9, Issue 3, pp. e91903, (2014) (PubMed).

Fernandes, Herlofsen, Karlsen, Küchler, Fløisand, Brinchmann: "Similar properties of chondrocytes from osteoarthritis joints and mesenchymal stem cells from healthy donors for tissue engineering of articular cartilage." in: PLoS ONE, Vol. 8, Issue 5, pp. e62994, (2013) (PubMed).

Boije, Harun-Or-Rashid, Lee, Imsland, Bruneau, Vieaud, Gourichon, Tixier-Boichard, Bedhom, Andersson, Hallböök: "Sonic Hedgehog-signalling patterns the developing chicken comb as revealed by exploration of the pea-comb mutation." in: PLoS ONE, Vol. 7, Issue 12, pp. e50890, (2012) (PubMed).

Yu, Deshmukh, Payton, Dunham, Scheithauer, Tihan, Prayson, Guha, Bridge, Ferner, Lindberg, Gutmann, Emnett, Salavaggione, Gutmann, Nagarajan, Watson, Perry: "Array-based comparative genomic hybridization identifies CDK4 and FOXM1 alterations as independent predictors of survival in malignant peripheral nerve sheath tumor." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 17, Issue 7, pp. 1924-34, (2011) (PubMed).

Aza-Carmona, Shears, Yuste-Checa, Barca-Tierno, Hisado-Oliva, Belinchón, Benito-Sanz, Rodríguez, Argente, Campos-Barros, Scambler, Heath: "SHOX interacts with the chondrogenic transcription factors SOX5 and SOX6 to activate the aggrecan enhancer." in: Human molecular genetics, Vol. 20, Issue 8, pp. 1547-59, (2011) (PubMed).

Kiselak, Shen, Song, Gude, Wang, Brody, Strauss, Zhang: "Transcriptional regulation of an axonemal central apparatus gene, sperm-associated antigen 6, by a SRY-related high mobility group transcription factor, S-SOX5." in: The Journal of biological chemistry, Vol. 285, Issue 40, pp. 30496-505, (2010) (PubMed).

Pytel, Karrison, Can Gong, Tonsgard, Krausz, Montag: "Neoplasms with schwannian differentiation express transcription factors known to regulate normal schwann cell development." in: International journal of surgical pathology, Vol. 18, Issue 6, pp. 449-57, (2010) (PubMed).

Torii, Hashimoto-Torii, Levitt, Rakic: "Integration of neuronal clones in the radial cortical columns by EphA and ephrin-A signalling." in: Nature, Vol. 461, Issue 7263, pp. 524-8, (2009) (PubMed).

Wright, Boije, Meadows, Bedhom, Gourichon, Vieaud, Tixier-Boichard, Rubin, Imsland, Hallböök, Andersson: "Copy number variation in intron 1 of SOX5 causes the Pea-comb phenotype in chickens." in: PLoS genetics, Vol. 5, Issue 6, pp. e1000512, (2009) (PubMed).

Tchougounova, Jiang, Bråsäter, Lindberg, Kastemar, Asplund, Westermark, Uhrbom: "Sox5 can suppress platelet-derived growth factor B-induced glioma development in Ink4a-deficient mice through induction of acute cellular senescence." in: Oncogene, Vol. 28, Issue 12, pp. 1537-48, (2009) (PubMed).

Martelli, Isella, Mira, Fu, Cantarella, Medico: "Exploiting orthologue diversity for systematic detection of gain-of-function phenotypes." in: BMC genomics, Vol. 9, pp. 254, (2008) (PubMed).

Details zu SOX5

Target: SOX5 (SRY (Sex Determining Region Y)-Box 5 (SOX5))

Andere Bezeichnung: SOX5

Hintergrund: SOX5 encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The encoded protein may play a role in chondrogenesis. A pseudogene of this gene is located on chromosome 8.
Alias Symbols: L-SOX5, MGC35153
Protein Interaction Partner: SUMO1P1, MORN3, PRR20A, FAM46B, CBX8, ZNF581, ARID5A, KAT5, CDC23, TAF6, SOX5, LMO2, LMO1, KIFC3, CRX, AES, MED27, UQCRFS1, TTC1, RPS2, SMAD7, SMAD5, SMAD1, FTH1, CDK6, CDC25A, APP, SOX2, SOX6,
Protein Size: 377

Molekulargewicht: 42 kDa

Gen-ID: 6660

NCBI Accession: NM_178010, NP_821078

UniProt: P35711