SOX18 Antikörper (Middle Region)

Produktnummer ABIN2777725

Es sind 3+ Publikationen für dieses Produkt verfügbar. Der Kaninchen Polyklonal anti-SOX18 Antikörper wird verwendet zum Nachweis von SOX18 in Proben von Human, Ratte, Maus, Rind (Kuh) und Meerschweinchen. Er wurde validiert für WB, IHC und IF.

Kurzübersicht für SOX18 Antikörper (Middle Region) (ABIN2777725)

Target: SOX18 (SRY (Sex Determining Region Y)-Box 18 (SOX18))

Reaktivität: Human, Ratte, Maus, Rind (Kuh), Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SOX18 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-SOX18 Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: SOX18 Antibody - middle region

Sequenz: RTAPPAAPLA GLYYGTLGTP GPYPGPLSPP PEAPPLESAE PLGPAADLWA

Homologie: Cow: 86%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against SOX18. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SOX18

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8112821

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-SOX18 Antikörper (ABIN2777725)

Park, Lee, Park, Choi, Lee, Song, Hwang, Hong, Nakaoka, Makinen, Kim, Alitalo, Hong, Koh: "Lymphatic regulator PROX1 determines Schlemm's canal integrity and identity." in: The Journal of clinical investigation, Vol. 124, Issue 9, pp. 3960-74, (2014) (PubMed).

Deng, Atri, Eichmann, Simons: "Endothelial ERK signaling controls lymphatic fate specification." in: The Journal of clinical investigation, Vol. 123, Issue 3, pp. 1202-15, (2013) (PubMed).

Duong, Proulx, Luciani, Leroux, Detmar, Koopman, Francois: "Genetic ablation of SOX18 function suppresses tumor lymphangiogenesis and metastasis of melanoma in mice." in: Cancer research, Vol. 72, Issue 12, pp. 3105-14, (2012) (PubMed).

Details zu SOX18

Target: SOX18 (SRY (Sex Determining Region Y)-Box 18 (SOX18))

Andere Bezeichnung: SOX18

Hintergrund:

Background Information: SOX18 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. This protein plays a role in hair, blood vessel, and lymphatic vessel development. Mutations in this gene have been associated with recessive and dominant forms of hypotrichosis-lymphedema-telangiectasia.

Gene Name: SRY (sex determining region Y)-box 18

Alternative Symbols: HLTS, HLTRS

Protein Name: Transcription factor SOX-18

Molekulargewicht: 41kDa

Gen-ID: 54345

NCBI Accession: NP_060889

UniProt: P35713