Aprataxin Antikörper (Middle Region)

Produktnummer ABIN2777648

Der Kaninchen Polyklonal anti-Aprataxin Antikörper wird verwendet zum Nachweis von Aprataxin in Proben von Human, Meerschweinchen, Hund, Pferd, Kaninchen und Rind (Kuh). Er wurde validiert für WB.

Kurzübersicht für Aprataxin Antikörper (Middle Region) (ABIN2777648)

Target: Aprataxin (APTX)

Reaktivität: Human, Meerschweinchen, Hund, Pferd, Kaninchen, Rind (Kuh)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Aprataxin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Aprataxin Antikörper

Bindungsspezifität: Middle Region

Sequenz: YPYIVEFEEE AKNPGLETHR KRKRSGNSDS IERDAAQEAE AGTGLEPGSN

Homologie: Cow: 77%, Dog: 86%, Guinea Pig: 79%, Horse: 92%, Human: 100%, Rabbit: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against APTX. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human APTX

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 306 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu Aprataxin

Target: Aprataxin (APTX)

Andere Bezeichnung: APTX

Hintergrund: APTX is a member of the histidine triad (HIT) superfamily, some of which have nucleotide-binding and diadenosine polyphosphate hydrolase activities. The protein may play a role in single-stranded DNA repair. Mutations in this gene have been associated with ataxia-ocular apraxia. Multiple transcript variants encoding distinct isoforms have been identified for this gene, however, the full length nature of some variants has not been determined. This gene encodes a member of the histidine triad (HIT) superfamily, some of which have nucleotide-binding and diadenosine polyphosphate hydrolase activities. The encoded protein may play a role in single-stranded DNA repair. Mutations in this gene have been associated with ataxia-ocular apraxia. Multiple transcript variants encoding distinct isoforms have been identified for this gene, however, the full length nature of some variants has not been determined.
Alias Symbols: AOA, AOA1, AXA1, EAOH, EOAHA, FHA-HIT, FLJ20157, MGC1072
Protein Interaction Partner: PNMA1, UBC, SUMO1, NEDD8, LIG3, HSPA4, XRCC1, DDX21, CNTROB, TSPYL2, CALCOCO1, SYT17, ZNF639, MAPKBP1, CEP350, PICK1, XRCC4, TRIM37, MBP, HIVEP1, BANF1, PARP1, TP53,
Protein Size: 306

Molekulargewicht: 35 kDa

Gen-ID: 54840

NCBI Accession: NM_175069, NP_778239

UniProt: Q5T782

Pathways: DNA Reparatur, Chromatin Binding