HNF4A Antikörper (N-Term)
Kurzübersicht für HNF4A Antikörper (N-Term) (ABIN2777514)
Target
Alle HNF4A Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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                                            Bindungsspezifität
- N-Term
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                                            Sequenz
- MRLSKTLVDM DMADYSAALD PAYTTLEFEN VQVLTMGNDT SPSEGTNLNA
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                                            Homologie
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 93%
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                                            Produktmerkmale
- This is a rabbit polyclonal antibody against HNF4A. It was validated on Western Blot.
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                                            Aufreinigung
- Affinity Purified
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                                            Immunogen
- The immunogen is a synthetic peptide directed towards the N-terminal region of Human HNF4A
 
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                                            Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
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                                            Kommentare
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                        Antigen size: 474 AA 
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                                            Beschränkungen
- Nur für Forschungszwecke einsetzbar
 
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                                            Format
- Liquid
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                                            Konzentration
- Lot specific
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                                            Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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                                            Konservierungsmittel
- Sodium azide
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                                            Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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                                            Handhabung
- Avoid repeated freeze-thaw cycles.
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                                            Lagerung
- -20 °C
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                                            Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
 
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    - 
                                            : "Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules."    in: Genome research, Vol. 22, Issue 11, pp. 2163-75, (2012)         (PubMed).        
 : "Five-vertebrate ChIP-seq reveals the evolutionary dynamics of transcription factor binding." in: Science (New York, N.Y.), Vol. 328, Issue 5981, pp. 1036-40, (2010) (PubMed).
 : "A CTCF-independent role for cohesin in tissue-specific transcription." in: Genome research, Vol. 20, Issue 5, pp. 578-88, (2010) (PubMed).
 : "Common variants of the hepatocyte nuclear factor-4alpha P2 promoter are associated with type 2 diabetes in the U.K. population." in: Diabetes, Vol. 53, Issue 11, pp. 3002-6, (2004) (PubMed).
 
 
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                                            : "Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules."    in: Genome research, Vol. 22, Issue 11, pp. 2163-75, (2012)         (PubMed).        
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    - HNF4A (Hepatocyte Nuclear Factor 4, alpha (HNF4A))
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                                            Andere Bezeichnung
- HNF4A
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                                            Hintergrund
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                        The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms.
 Alias Symbols: HNF4, HNF4a7, HNF4a8, HNF4a9, HNF4alpha, MODY, MODY1, NR2A1, NR2A21, TCF, TCF14
 Protein Interaction Partner: PIAS4, SUMO1, SUMO2, RNF4, SUB1, CREBBP, TBP, TAF9, TAF6, TADA2A, GTF2H1, GTF2B, ANP32B, MDM2, GPS2, PPARGC1A, HNF4A, NCOA6, SMAD4, SMAD3, PNRC2, COPS5, PNRC1, NR0B2, NRIP1, UBE2I, PROX1, NPPA, SREBF2, VDR, MAPK3, MAPK1, SIRT1, SREBF1, XPO1, SP1, HDAC3, T
 Protein Size: 474
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                                            Molekulargewicht
- 53 kDa
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                                            Gen-ID
- 3172
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                                            NCBI Accession
- NM_000457, NP_000448
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                                            UniProt
- P41235
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                                            Pathways
- AMPK Signaling, Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Carbohydrate Homeostasis, Cell-Cell Junction Organization, Regulation of Carbohydrate Metabolic Process
 Target
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