HNF4A Antikörper (N-Term)

Produktnummer ABIN2777514

Der Rabbit Polyclonal Anti-HNF4A-Antikörper wurde für WB validiert. Er ist geeignet, HNF4A in Proben von Human, Mouse, Rat, Cow, Dog, Horse, Rabbit, Guinea Pig, Sheep, Zebrafish (Danio rerio) zu detektieren. Es sind 4+ Publikationen verfügbar.

Kurzübersicht für HNF4A Antikörper (N-Term) (ABIN2777514)

Target: HNF4A (Hepatocyte Nuclear Factor 4, alpha (HNF4A))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Pferd, Kaninchen, Meerschweinchen, Schaf, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HNF4A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-HNF4A Antikörper

Bindungsspezifität: N-Term

Sequenz: MRLSKTLVDM DMADYSAALD PAYTTLEFEN VQVLTMGNDT SPSEGTNLNA

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against HNF4A. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human HNF4A

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 474 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-HNF4A Antikörper (ABIN2777514)

Faure, Schmidt, Watt, Schwalie, Wilson, Xu, Ramsay, Odom, Flicek: "Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules." in: Genome research, Vol. 22, Issue 11, pp. 2163-75, (2012) (PubMed).

Schmidt, Wilson, Ballester, Schwalie, Brown, Marshall, Kutter, Watt, Martinez-Jimenez, Mackay, Talianidis, Flicek, Odom: "Five-vertebrate ChIP-seq reveals the evolutionary dynamics of transcription factor binding." in: Science (New York, N.Y.), Vol. 328, Issue 5981, pp. 1036-40, (2010) (PubMed).

Schmidt, Schwalie, Ross-Innes, Hurtado, Brown, Carroll, Flicek, Odom: "A CTCF-independent role for cohesin in tissue-specific transcription." in: Genome research, Vol. 20, Issue 5, pp. 578-88, (2010) (PubMed).

Weedon, Owen, Shields, Hitman, Walker, McCarthy, Love-Gregory, Permutt, Hattersley, Frayling: "Common variants of the hepatocyte nuclear factor-4alpha P2 promoter are associated with type 2 diabetes in the U.K. population." in: Diabetes, Vol. 53, Issue 11, pp. 3002-6, (2004) (PubMed).

Details zu HNF4A

Target: HNF4A (Hepatocyte Nuclear Factor 4, alpha (HNF4A))

Andere Bezeichnung: HNF4A

Hintergrund: The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms.
Alias Symbols: HNF4, HNF4a7, HNF4a8, HNF4a9, HNF4alpha, MODY, MODY1, NR2A1, NR2A21, TCF, TCF14
Protein Interaction Partner: PIAS4, SUMO1, SUMO2, RNF4, SUB1, CREBBP, TBP, TAF9, TAF6, TADA2A, GTF2H1, GTF2B, ANP32B, MDM2, GPS2, PPARGC1A, HNF4A, NCOA6, SMAD4, SMAD3, PNRC2, COPS5, PNRC1, NR0B2, NRIP1, UBE2I, PROX1, NPPA, SREBF2, VDR, MAPK3, MAPK1, SIRT1, SREBF1, XPO1, SP1, HDAC3, T
Protein Size: 474

Molekulargewicht: 53 kDa

Gen-ID: 3172

NCBI Accession: NM_000457, NP_000448

UniProt: P41235

Pathways: AMPK Signaling, Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Carbohydrate Homeostasis, Cell-Cell Junction Organization, Regulation of Carbohydrate Metabolic Process