FOXA2 Antikörper (Middle Region)

Produktnummer ABIN2777512

Es sind 3+ Publikationen für dieses Produkt verfügbar. Der Kaninchen Polyklonal anti-FOXA2 Antikörper wird verwendet zum Nachweis von FOXA2 in Proben von Human, Ratte, Maus, Hund, Kaninchen, Pferd und Schwein. Er wurde validiert für WB.

Kurzübersicht für FOXA2 Antikörper (Middle Region) (ABIN2777512)

Target: FOXA2 (Forkhead Box A2 (FOXA2))

Reaktivität: Human, Ratte, Maus, Hund, Kaninchen, Pferd, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FOXA2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-FOXA2 Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: FOXA2 Antibody - middle region

Sequenz: ASQAQLGEAA GPASETPAGT ESPHSSASPC QEHKRGGLGE LKGTPAAALS

Homologie: Dog: 100%, Horse: 100%, Human: 100%, Mouse: 92%, Pig: 100%, Rabbit: 77%, Rat: 92%

Produktmerkmale: This is a rabbit polyclonal antibody against FOXA2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human FOXA2

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP31944-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-FOXA2 Antikörper (ABIN2777512)

Kallas, Pook, Trei, Maimets: "SOX2 Is Regulated Differently from NANOG and OCT4 in Human Embryonic Stem Cells during Early Differentiation Initiated with Sodium Butyrate." in: Stem cells international, Vol. 2014, pp. 298163, (2014) (PubMed).

Menga, Infantino, Iacobazzi, Convertini, Palmieri, Iacobazzi: "Insight into mechanism of in vitro insulin secretion increase induced by antipsychotic clozapine: role of FOXA1 and mitochondrial citrate carrier." in: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, Vol. 23, Issue 8, pp. 978-87, (2013) (PubMed).

Richards, Park, Chen, Gibson, Peter Di, Pardo, Watkins, Choi, Selman, Pilewski, Kaminski, Zhang: "Allele-specific transactivation of matrix metalloproteinase 7 by FOXA2 and correlation with plasma levels in idiopathic pulmonary fibrosis." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 302, Issue 8, pp. L746-54, (2012) (PubMed).

Details zu FOXA2

Target: FOXA2 (Forkhead Box A2 (FOXA2))

Andere Bezeichnung: FOXA2

Hintergrund:

Background Information: FOXA2 is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young.This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Two transcript variants encoding the same protein have been identified for this gene. This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Two transcript variants encoding the same protein have been identified for this gene.

Gene Name: Forkhead box A2

Alternative Symbols: HNF3B, TCF3B, HNF-3-beta

Protein Name: Hepatocyte nuclear factor 3-beta

Molekulargewicht: 48kDa

Gen-ID: 3170

NCBI Accession: NP_068556

UniProt: Q9Y261

Pathways: Dopaminergic Neurogenesis, Regulation of Carbohydrate Metabolic Process