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FOXA2 Antikörper (Middle Region)

Der Kaninchen Polyklonal Anti-FOXA2-Antikörper wurde für WB validiert. Er ist geeignet, FOXA2 in Proben von Human, Maus, Ratte, Hund, Kaninchen, Pferd und Schwein zu detektieren. Es sind 3+ Publikationen verfügbar.
Produktnummer ABIN2777512

Kurzübersicht für FOXA2 Antikörper (Middle Region) (ABIN2777512)

Target

Alle FOXA2 Antikörper anzeigen
FOXA2 (Forkhead Box A2 (FOXA2))

Reaktivität

  • 85
  • 30
  • 15
  • 5
  • 5
  • 5
  • 3
  • 3
  • 3
  • 3
  • 1
  • 1
Human, Maus, Ratte, Hund, Kaninchen, Pferd, Schwein

Wirt

  • 80
  • 9
  • 2
Kaninchen

Klonalität

  • 73
  • 18
Polyklonal

Konjugat

  • 52
  • 5
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser FOXA2 Antikörper ist unkonjugiert

Applikation

  • 76
  • 37
  • 31
  • 20
  • 17
  • 14
  • 13
  • 11
  • 10
  • 7
  • 4
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB)
  • Bindungsspezifität

    • 16
    • 9
    • 8
    • 8
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region

    Sequenz

    ASQAQLGEAA GPASETPAGT ESPHSSASPC QEHKRGGLGE LKGTPAAALS

    Homologie

    Dog: 100%, Horse: 100%, Human: 100%, Mouse: 92%, Pig: 100%, Rabbit: 77%, Rat: 92%

    Produktmerkmale

    This is a rabbit polyclonal antibody against FOXA2. It was validated on Western Blot using a cell lysate as a positive control.

    Aufreinigung

    Affinity Purified

    Immunogen

    The immunogen is a synthetic peptide directed towards the middle region of human FOXA2
  • Applikationshinweise

    Optimal working dilutions should be determined experimentally by the investigator.

    Kommentare

    Antigen size: 457 AA

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    Lot specific

    Buffer

    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freeze-thaw cycles.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Kallas, Pook, Trei, Maimets: "SOX2 Is Regulated Differently from NANOG and OCT4 in Human Embryonic Stem Cells during Early Differentiation Initiated with Sodium Butyrate." in: Stem cells international, Vol. 2014, pp. 298163, (2014) (PubMed).

    Menga, Infantino, Iacobazzi, Convertini, Palmieri, Iacobazzi: "Insight into mechanism of in vitro insulin secretion increase induced by antipsychotic clozapine: role of FOXA1 and mitochondrial citrate carrier." in: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, Vol. 23, Issue 8, pp. 978-87, (2013) (PubMed).

    Richards, Park, Chen, Gibson, Peter Di, Pardo, Watkins, Choi, Selman, Pilewski, Kaminski, Zhang: "Allele-specific transactivation of matrix metalloproteinase 7 by FOXA2 and correlation with plasma levels in idiopathic pulmonary fibrosis." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 302, Issue 8, pp. L746-54, (2012) (PubMed).

  • Target

    FOXA2 (Forkhead Box A2 (FOXA2))

    Andere Bezeichnung

    FOXA2

    Hintergrund

    FOXA2 is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young.This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Two transcript variants encoding the same protein have been identified for this gene. This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Two transcript variants encoding the same protein have been identified for this gene.
    Alias Symbols: HNF3B, MGC19807, TCF3B
    Protein Interaction Partner: PPARGC1B, GSC, EN2, OTX2, ONECUT1, NCOA1, TLE1, MIP, HOXA5, LHX1,
    Protein Size: 457

    Molekulargewicht

    48 kDa

    Gen-ID

    3170

    NCBI Accession

    NM_021784, NP_068556

    UniProt

    Q9Y261

    Pathways

    Dopaminergic Neurogenesis, Regulation of Carbohydrate Metabolic Process
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