NFE2 Antikörper (N-Term)

Produktnummer ABIN2777230

Produktdetails anti-NFE2 Antikörper

Target: NFE2 (Nuclear Factor (Erythroid-Derived 2), 45kDa (NFE2))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Pferd, Rind (Kuh), Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NFE2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: MSPCPPQQSR NRVIQLSTSE LGEMELTWQE IMSITELQGL NAPSEPSFEP

Homologie: Cow: 92%, Guinea Pig: 87%, Horse: 87%, Human: 100%, Mouse: 77%, Rat: 92%

Produktmerkmale: This is a rabbit polyclonal antibody against NFE2. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human NFE2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 373 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu NFE2

Target: NFE2 (Nuclear Factor (Erythroid-Derived 2), 45kDa (NFE2))

Andere Bezeichnung: NFE2 (NFE2 Produkte)

Hintergrund: NFE2 is a component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. NFE2 binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. NFE2 is requires MAFK or other small MAF proteins for binding to the NF-E2 motif. NFE2 may play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron.
Alias Symbols: NF-E2, p45
Protein Interaction Partner: BTRC, NFE2L3, NFE2L2, NFE2, ATF4, Dlg4, TXN, ITCH, Yap1, Nedd4, WWP1, MAPK8, KAT2B, SCAND1, SSX5, HMGN1, ELF5, PHYHIP, MAFF, MAFG, PEX14, MAFK, CREBBP,
Protein Size: 373

Molekulargewicht: 41 kDa

Gen-ID: 4778

NCBI Accession: NM_006163, NP_006154

UniProt: Q16621