Androgen Receptor Antikörper (N-Term)

Produktnummer ABIN2777192

Produktdetails anti-Androgen Receptor Antikörper

Target: Androgen Receptor (AR)

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Schwein, Hund, Rind (Kuh), Pferd, Kaninchen, Meerschweinchen, Schaf

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Androgen Receptor Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: MEVQLGLGRV YPRPPSKTYR GAFQNLFQSV REVIQNPGPR HPEAASAAPP

Homologie: Cow: 86%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 86%, Rat: 93%, Sheep: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against AR. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human AR

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 920 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu Androgen Receptor

Target: Androgen Receptor (AR)

Andere Bezeichnung: AR (AR Produkte)

Synonyme: AIS antikoerper, DHTR antikoerper, HUMARA antikoerper, HYSP1 antikoerper, KD antikoerper, NR3C4 antikoerper, SBMA antikoerper, SMAX1 antikoerper, TFM antikoerper, AW320017 antikoerper, Tfm antikoerper, Andr antikoerper, AR antikoerper, androgen receptor antikoerper, AR antikoerper, Ar antikoerper, ar antikoerper

Hintergrund: AR has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS).The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.
Alias Symbols: AIS, DHTR, HUMARA, KD, NR3C4, SBMA, SMAX1, TFM, HYSP1
Protein Interaction Partner: AATF, SPOP, UBC, TSG101, TAF1, EP300, DAPK3, USP12, TTC5, SIRT1, RNF6, MAGEA11, VCP, KIF1A, NSD1, WIPI1, NDE1, NCOA1, REL, SMAD1, WDR77, AR, RANBP9, VHL, SKP2, RNF14, EZH2, BMI1, DCAF6, SUZ12, EED, RNF2, RBL1, PTGES3, NCOA4, SUMO2, CUL2, UXT, TCF4, ACTB,
Protein Size: 920

Molekulargewicht: 99 kDa

Gen-ID: 367

NCBI Accession: NM_000044, NP_000035

UniProt: P10275

Pathways: Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Chromatin Binding