CBFB Antikörper (N-Term)

Produktnummer ABIN2777178

Produktdetails anti-CBFB Antikörper

Target: CBFB (Core-Binding Factor, beta Subunit (CBFB))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Zebrafisch (Danio rerio), Pferd, Rind (Kuh), Hund, Schwein, Kaninchen, Meerschweinchen, Saccharomyces cerevisiae

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CBFB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: MPRVVPDQRS KFENEEFFRK LSRECEIKYT GFRDRPHEER QARFQNACRD

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 79%, Horse: 79%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Yeast: 82%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against CBFB. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human CBFB

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 182 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu CBFB

Target: CBFB (Core-Binding Factor, beta Subunit (CBFB))

Andere Bezeichnung: CBFB (CBFB Produkte)

Synonyme: PEBP2B antikoerper, Cbfb antikoerper, pebp2b antikoerper, Pebp2 antikoerper, CBFB antikoerper, unp1266 antikoerper, cbf-beta antikoerper, cbfbeta antikoerper, pea2-beta antikoerper, pebp2-beta antikoerper, AI893578 antikoerper, PEA2 antikoerper, PEBP2b antikoerper, Pebpb2 antikoerper, core-binding factor beta subunit antikoerper, core binding factor beta subunit antikoerper, core-binding factor, beta subunit antikoerper, core-binding factor, beta subunit S homeolog antikoerper, core binding factor beta antikoerper, CBFB antikoerper, Cbfb antikoerper, cbfb antikoerper, cbfb.S antikoerper

Hintergrund: CBFB encodes a protein that is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit, it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters.
Alias Symbols: PEBP2B
Protein Interaction Partner: vif, CUL5, UBC, RAB2A, MYC, nef, APOBEC3G, RUNX1, ELAVL1, KMT2A, COPRS, RUNX3, MYOD1, CHGB, CBFA2T2, RUNX2, CBFB, C1QBP,
Protein Size: 182

Molekulargewicht: 21 kDa

Gen-ID: 865

NCBI Accession: NM_001755, NP_001746

UniProt: Q13951

Pathways: Regulation of Lipid Metabolism by PPARalpha