Ret Proto-Oncogene Antikörper (C-Term)

Produktnummer ABIN2777172

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Ret Proto-Oncogene in WB. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte, Rind (Kuh), Schwein, Kaninchen, Zebrafisch (Danio rerio), Hund, Meerschweinchen und Pferd.

Kurzübersicht für Ret Proto-Oncogene Antikörper (C-Term) (ABIN2777172)

Target: Ret Proto-Oncogene (RET)

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Schwein, Kaninchen, Zebrafisch (Danio rerio), Hund, Meerschweinchen, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Ret Proto-Oncogene Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Ret Proto-Oncogene Antikörper

Bindungsspezifität: C-Term

Sequenz: EMKLVHRDLA ARNILVAEGR KMKISDFGLS RDVYEEDSYV KRSQGRIPVK

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 90%, Horse: 100%, Human: 100%, Mouse: 90%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against RET. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 1114 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu Ret Proto-Oncogene

Target: Ret Proto-Oncogene (RET)

Andere Bezeichnung: RET

Hintergrund: This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed.
Alias Symbols: CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET-ELE1, RET51
Protein Interaction Partner: NOTCH2NL, UBC, CBLC, PDLIM7, HSP90AA1, GRB2, CBL, RET, MCRS1, IKBKG, DOK3, DOK5, DOK4, DOK6, SHC3, FRS2, DOK2, AKAP5, CBLB, GAB1, DOK1, NRTN, MAPK3, GRB10, GRB7, GFRA1, MAPK8, GDNF, PTK2, SHC1, MAPK14, SRC, MAPK1, PRKAR2A, PTPN11, PLCG1, PIK3R1, CRK, STAT
Protein Size: 1114

Molekulargewicht: 123 kDa

Gen-ID: 5979

NCBI Accession: NM_000323, NP_000314

UniProt: P07949

Pathways: RTK Signalweg, Dopaminergic Neurogenesis, Regulation of Cell Size, Tube Formation