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GSTM1 Antikörper (N-Term)

This anti-GSTM1 antibody (ABIN2776984) is a Rabbit Polyclonal antibody detecting GSTM1 in WB. Suitable for Human, Mouse, Rat, Dog, Cow, Rabbit, Guinea Pig, Horse, Goat, Sheep.
Produktnummer ABIN2776984

Quick Overview for GSTM1 Antikörper (N-Term) (ABIN2776984)

Target

Alle GSTM1 Antikörper anzeigen
GSTM1 (Glutathione S-Transferase mu 1 (GSTM1))

Reaktivität

  • 49
  • 37
  • 15
  • 8
  • 4
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Human, Maus, Ratte, Hund, Rind (Kuh), Kaninchen, Meerschweinchen, Pferd, Ziege, Schaf

Wirt

  • 66
  • 13
  • 1
  • 1
Kaninchen

Klonalität

  • 66
  • 14
Polyklonal

Konjugat

  • 48
  • 15
  • 9
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
Dieser GSTM1 Antikörper ist unkonjugiert

Applikation

  • 67
  • 42
  • 25
  • 23
  • 11
  • 11
  • 11
  • 5
  • 4
  • 3
  • 3
  • 2
  • 1
  • 1
Western Blotting (WB)
  • Bindungsspezifität

    • 21
    • 9
    • 6
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term

    Sequenz

    KKYTMGDAPD YDRSQWLNEK FKLGLDFPNL PYLIDGAHKI TQSNAILCYI

    Homologie

    Cow: 100%, Dog: 100%, Goat: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 93%

    Produktmerkmale

    This is a rabbit polyclonal antibody against GSTM1. It was validated on Western Blot using a cell lysate as a positive control.

    Aufreinigung

    Affinity Purified

    Immunogen

    The immunogen is a synthetic peptide directed towards the N terminal region of human GSTM1
  • Applikationshinweise

    Optimal working dilutions should be determined experimentally by the investigator.

    Kommentare

    Antigen size: 218 AA

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    Lot specific

    Buffer

    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freeze-thaw cycles.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Zachut, Kra, Livshitz, Portnick, Yakoby, Friedlander, Levin: "Seasonal heat stress affects adipose tissue proteome toward enrichment of the Nrf2-mediated oxidative stress response in late-pregnant dairy cows." in: Journal of proteomics, Vol. 158, pp. 52-61, (2017) (PubMed).

    Bates, Li, Liang, Sarojini, An, Masternak, Bartke, Wang: "MicroRNA regulation in Ames dwarf mouse liver may contribute to delayed aging." in: Aging cell, Vol. 9, Issue 1, pp. 1-18, (2010) (PubMed).

  • Target

    GSTM1 (Glutathione S-Transferase mu 1 (GSTM1))

    Andere Bezeichnung

    GSTM1

    Hintergrund

    Cytosolic and membrane-bound forms of glutathione S-transferase are two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. GSTM1 a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione.Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene.
    Alias Symbols: GST1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, GTM1, H-B, MGC26563, MU, MU-1
    Protein Interaction Partner: GSTM3, UBC, IQCB1, MAP3K5, GSTM2, GSTM1,
    Protein Size: 218

    Molekulargewicht

    26 kDa

    Gen-ID

    2944

    NCBI Accession

    NM_000561, NP_000552

    UniProt

    P46439

    Pathways

    Negative Regulation of Transporter Activity
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