HMGCS2 Antikörper (N-Term)

Produktnummer ABIN2776880

Der Kaninchen Polyklonal Anti-HMGCS2-Antikörper wurde für WB validiert. Er ist geeignet, HMGCS2 in Proben von Human, Maus, Ratte, Hund, Meerschweinchen, Kaninchen, Ziege, Pferd und Rind (Kuh) zu detektieren. Es sind 2+ Publikationen verfügbar.

Kurzübersicht für HMGCS2 Antikörper (N-Term) (ABIN2776880)

Target: HMGCS2 (3-Hydroxy-3-Methylglutaryl-CoA Synthase 2 (Mitochondrial) (HMGCS2))

Reaktivität: Human, Maus, Ratte, Hund, Meerschweinchen, Kaninchen, Ziege, Pferd, Rind (Kuh)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HMGCS2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-HMGCS2 Antikörper

Bindungsspezifität: N-Term

Sequenz: PKDVGILALE VYFPAQYVDQ TDLEKYNNVE AGKYTVGLGQ TRMGFCSVQE

Homologie: Cow: 93%, Dog: 100%, Goat: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against HMGCS2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human HMGCS2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 508 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-HMGCS2 Antikörper (ABIN2776880)

Clara, Schumacher, Ramachandran, Fedele, Krieger, Langhans, Mansouri: "Metabolic Adaptation of the Small Intestine to Short- and Medium-Term High-Fat Diet Exposure." in: Journal of cellular physiology, Vol. 232, Issue 1, pp. 167-75, (2016) (PubMed).

Karimian Azari, Leitner, Jaggi, Langhans, Mansouri: "Possible role of intestinal fatty acid oxidation in the eating-inhibitory effect of the PPAR-? agonist Wy-14643 in high-fat diet fed rats." in: PLoS ONE, Vol. 8, Issue 9, pp. e74869, (2013) (PubMed).

Details zu HMGCS2

Target: HMGCS2 (3-Hydroxy-3-Methylglutaryl-CoA Synthase 2 (Mitochondrial) (HMGCS2))

Andere Bezeichnung: HMGCS2

Hintergrund: HMGCS2 condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
Protein Interaction Partner: UBC, APP, YWHAQ,
Protein Size: 508

Molekulargewicht: 56 kDa

Gen-ID: 3158

NCBI Accession: NM_005518, NP_005509

UniProt: P54868

Pathways: Response to Growth Hormone Stimulus, Cellular Response to Molecule of Bacterial Origin, Regulation of Lipid Metabolism by PPARalpha