FZD8 Antikörper (N-Term)

Produktnummer ABIN2776728

Dieses Anti-FZD8-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von FZD8 in WB. Geeignet für Human, Maus, Ratte und Hund. Dieses Primary Antibody wurde in 2+ Publikationen zitiert.

Kurzübersicht für FZD8 Antikörper (N-Term) (ABIN2776728)

Target: FZD8 (Frizzled Family Receptor 8 (FZD8))

Reaktivität: Human, Maus, Ratte, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FZD8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-FZD8 Antikörper

Bindungsspezifität: N-Term

Sequenz: PDTLCMDYNR TDLTTAAPSP PRRLPPPPPG EQPPSGSGHG RPPGARPPHR

Homologie: Dog: 100%, Human: 100%, Mouse: 93%, Rat: 92%

Produktmerkmale: This is a rabbit polyclonal antibody against FZD8. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human FZD8

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 694 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-FZD8 Antikörper (ABIN2776728)

Xu, Wen, Liu, Xu, Yang, Liu, Feng, An: "MicroRNA-375 suppresses human colorectal cancer metastasis by targeting Frizzled 8." in: Oncotarget, Vol. 7, Issue 26, pp. 40644-40656, (2016) (PubMed).

Yin, Xu, Bonfil, Banerjee, Sarkar, Sethi, Reddy: "Tumor-initiating cells and FZD8 play a major role in drug resistance in triple-negative breast cancer." in: Molecular cancer therapeutics, Vol. 12, Issue 4, pp. 491-8, (2013) (PubMed).

Details zu FZD8

Target: FZD8 (Frizzled Family Receptor 8 (FZD8))

Andere Bezeichnung: FZD8

Hintergrund: FZD8 is a member of the frizzled family. Members of this family are seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.
Alias Symbols: FZ-8, hFZ8
Protein Interaction Partner: WNT1, LRP5, LRP6, SUMO1, GOPC, RYK,
Protein Size: 694

Molekulargewicht: 73 kDa

Gen-ID: 8325

NCBI Accession: NM_031866, NP_114072

UniProt: Q9H461

Pathways: WNT Signalweg