ZIC2 Antikörper (C-Term)

Produktnummer ABIN2776475

Dieses Anti-ZIC2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von ZIC2 in WB und IHC. Geeignet für Human, Ratte, Maus und Meerschweinchen. Dieses Primary Antibody wurde in 4+ Publikationen zitiert.

Kurzübersicht für ZIC2 Antikörper (C-Term) (ABIN2776475)

Target: ZIC2

Reaktivität: Human, Ratte, Maus, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ZIC2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-ZIC2 Antikörper

Bindungsspezifität: C-Term

Sequenz: EPQSSSNLSP AAAAAAAAAA AAAAAVSAVH RGGGSGSGGA GGGSGGGSGS

Homologie: Guinea Pig: 87%, Human: 100%, Mouse: 85%, Rat: 92%

Produktmerkmale: This is a rabbit polyclonal antibody against ZIC2. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human ZIC2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 532 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-ZIC2 Antikörper (ABIN2776475)

Toth, Schiffmann, Hube-Magg, Büscheck, Höflmayer, Weidemann, Lebok, Fraune, Minner, Schlomm, Sauter, Plass, Assenov, Simon, Meiners, Gerhäuser: "Random forest-based modelling to detect biomarkers for prostate cancer progression." in: Clinical epigenetics, Vol. 11, Issue 1, pp. 148, (2020) (PubMed).

Inaguma, Ito, Riku, Ikeda, Kasai: "Addiction of pancreatic cancer cells to zinc-finger transcription factor ZIC2." in: Oncotarget, Vol. 6, Issue 29, pp. 28257-68, (2015) (PubMed).

Zhu, Wang, He, Huang, Du, Zhang, Yan, Xia, Ye, Wang, Hao, Wu, Fan: "ZIC2-dependent OCT4 activation drives self-renewal of human liver cancer stem cells." in: The Journal of clinical investigation, Vol. 125, Issue 10, pp. 3795-808, (2015) (PubMed).

McCampbell, Truong, Broom, Allchorne, Gable, Cutler, Mattson, Woolf, Frosch, Harmon, Dunn, Brown: "Mutant SPTLC1 dominantly inhibits serine palmitoyltransferase activity in vivo and confers an age-dependent neuropathy." in: Human molecular genetics, Vol. 14, Issue 22, pp. 3507-21, (2005) (PubMed).

Details zu ZIC2

Target: ZIC2

Andere Bezeichnung: ZIC2

Hintergrund: ZIC2 is a member of the ZIC family of C2H2-type zinc finger proteins. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Mutations in this gene cause holoprosencephaly type 5. Holoprosencephaly is the most common structural anomaly of the human brain. A polyhistidine tract polymorphism in this gene may be associated with increased risk of neural tube defects.This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Mutations in this gene cause holoprosencephaly type 5. Holoprosencephaly is the most common structural anomaly of the human brain. A polyhistidine tract polymorphism in this gene may be associated with increased risk of neural tube defects. This gene is closely linked to a gene encoding zinc finger protein of the cerebellum 5, a related family member on chromosome 13.
Alias Symbols: HPE5
Protein Interaction Partner: SUMO1, ELAVL1, GLI3, GLI2, GLI1, RNF180, UBC,
Protein Size: 532

Molekulargewicht: 55 kDa

Gen-ID: 7546

NCBI Accession: NM_007129, NP_009060

UniProt: O95409

Pathways: Tube Formation