YBX1 Antikörper (Middle Region)

Produktnummer ABIN2775773

Dieser Kaninchen Polyklonal Antikörper erkennt spezifisch YBX1 in WB und IHC. Er zeigt eine Reaktivität gegenüber Human, Ratte, Maus, Rind (Kuh), Hund, Schaf, Pferd, Kaninchen und Meerschweinchen.

Kurzübersicht für YBX1 Antikörper (Middle Region) (ABIN2775773)

Target: YBX1 (Y Box Binding Protein 1 (YBX1))

Reaktivität: Human, Ratte, Maus, Rind (Kuh), Hund, Schaf, Pferd, Kaninchen, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser YBX1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-YBX1 Antikörper

Bindungsspezifität: Middle Region

Sequenz: NHYRRYPRRR GPPRNYQQNY QNSESGEKNE GSESAPEGQA QQRRPYRRRR

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against YBX1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human YBX1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 324 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu YBX1

Target: YBX1 (Y Box Binding Protein 1 (YBX1))

Andere Bezeichnung: YBX1

Hintergrund: YBX1 binds to splice sites in pre-mRNA and regulates splice site selection. YBX1 binds and stabilizes cytoplasmic mRNA. YBX1 contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors. YBX1 binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as HLA class II genes. YBX1 regulates the transcription of numerous genes. YBX1 promotes separation of DNA strands that contain mismatches or are modified by cisplatin. YBX1 has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro). YBX1 may play a role in DNA repair. YBX1 is the component of the CRD-mediated complex that promotes MYC mRNA stability.
Alias Symbols: BP-8, CSDA2, CSDB, DBPB, MDR-NF1, MGC104858, MGC110976, MGC117250, NSEP-1, NSEP1, YB-1, YB1
Protein Interaction Partner: UBC, TP53, AKT1, SPRTN, AURKA, SUMO2, STAU1, IVNS1ABP, SMURF2, EZH2, BMI1, SUZ12, RNF2, HNRNPU, HNRNPAB, HNRNPA2B1, FUS, FKBP3, DYNC1LI2, DYNC1I2, DYNC1H1, DDX1, APBB1, G3BP1, EIF2B2, TUBB, PRPF40A, EIF3K, DIMT1, TUBA4A, RPL23A, PTBP1, PA2G4, NMT1, MAP2,
Protein Size: 324

Molekulargewicht: 36 kDa

Gen-ID: 4904

NCBI Accession: NM_004559, NP_004550

UniProt: P67809

Pathways: Regulation of Muscle Cell Differentiation