UPB1 Antikörper (Middle Region)

Produktnummer ABIN2775431

Zitiert in 2+ Publikationen. Der Kaninchen Polyklonal anti-UPB1 Antikörper (ABIN2775431) detektiert spezifisch UPB1 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus, Ratte, Hund, Zebrafisch (Danio rerio), Pferd, Rind (Kuh), Meerschweinchen, Kaninchen und Ziege.

Kurzübersicht für UPB1 Antikörper (Middle Region) (ABIN2775431)

Target: UPB1 (Ureidopropionase, beta (UPB1))

Reaktivität: Human, Maus, Ratte, Hund, Zebrafisch (Danio rerio), Pferd, Rind (Kuh), Meerschweinchen, Kaninchen, Ziege

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UPB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-UPB1 Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: UPB1 Antibody - middle region

Sequenz: AVVISNSGAV LGKTRKNHIP RVGDFNESTY YMEGNLGHPV FQTQFGRIAV

Homologie: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against UPB1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human UPB1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8115518

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-UPB1 Antikörper (ABIN2775431)

Kunicka, Prochazka, Krus, Bendova, Protivova, Susova, Hlavac, Liska, Novak, Schneiderova, Pitule, Bruha, Vycital, Vodicka, Soucek: "Molecular profile of 5-fluorouracil pathway genes in colorectal carcinoma." in: BMC cancer, Vol. 16, Issue 1, pp. 795, (2016) (PubMed).

Hu, Lausted, Yoo, Yan, Brightman, Chen, Wang, Bu, Hood: "Quantitative liver-specific protein fingerprint in blood: a signature for hepatotoxicity." in: Theranostics, Vol. 4, Issue 2, pp. 215-28, (2014) (PubMed).

Details zu UPB1

Target: UPB1 (Ureidopropionase, beta (UPB1))

Andere Bezeichnung: UPB1

Hintergrund:

Background Information: UPB1 is a protein that belongs to the CN hydrolase family. Beta-ureidopropionase catalyzes the last step in the pyrimidine degradation pathway. The pyrimidine bases uracil and thymine are degraded via the consecutive action of dihydropyrimidine dehydrogenase (DHPDH), dihydropyrimidinase (DHP) and beta-ureidopropionase (UP) to beta-alanine and beta-aminoisobutyric acid, respectively. UP deficiencies are associated with N-carbamyl-beta-amino aciduria and may lead to abnormalities in neurological activityThis gene encodes a protein that belongs to the CN hydrolase family. Beta-ureidopropionase catalyzes the last step in the pyrimidine degradation pathway. The pyrimidine bases uracil and thymine are degraded via the consecutive action of dihydropyrimidine dehydrogenase (DHPDH), dihydropyrimidinase (DHP) and beta-ureidopropionase (UP) to beta-alanine and beta-aminoisobutyric acid, respectively. UP deficiencies are associated with N-carbamyl-beta-amino aciduria and may lead to abnormalities in neurological activity.

Gene Name: Ureidopropionase, beta

Alternative Symbols: BUP1

Protein Name: Beta-ureidopropionase

Molekulargewicht: 42kDa

Gen-ID: 51733

NCBI Accession: NP_057411

UniProt: Q9UBR1