PPP2R3B Antikörper (C-Term)

Produktnummer ABIN2775379

Zitiert in 1 Publikation. Der Kaninchen Polyklonal anti-PPP2R3B Antikörper (ABIN2775379) detektiert spezifisch PPP2R3B in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus, Ratte, Hund, Rind (Kuh), Zebrafisch (Danio rerio), Meerschweinchen, Pferd und Kaninchen.

Kurzübersicht für PPP2R3B Antikörper (C-Term) (ABIN2775379)

Target: PPP2R3B (Protein Phosphatase 2A 48 KDa Regulatory Subunit (PPP2R3B))

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Zebrafisch (Danio rerio), Meerschweinchen, Pferd, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PPP2R3B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PPP2R3B Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: PPP2R3B Antibody - C-terminal region

Sequenz: TFFNIEKYLD HEQKEQISLL RDGDSGGPEL SDWEKYAAEE YDILVAEETA

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 77%, Horse: 77%, Human: 100%, Mouse: 77%, Rabbit: 77%, Rat: 82%, Zebrafish: 85%

Produktmerkmale: This is a rabbit polyclonal antibody against PPP2R3B. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human PPP2R3B

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP42370-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-PPP2R3B Antikörper (ABIN2775379)

van Kempen, Redpath, Elchebly, Klein, Papadakis, Wilmott, Scolyer, Edqvist, Pontén, Schadendorf, van Rijk, Michiels, Dumay, Helbling-Leclerc, Dessen, Wouters, Stass, Greenwood, Ghanem, van den Oord et al.: "The protein phosphatase 2A regulatory subunit PR70 is a gonosomal melanoma tumor suppressor gene. ..." in: Science translational medicine, Vol. 8, Issue 369, pp. 369ra177, (2016) (PubMed).

Details zu PPP2R3B

Target: PPP2R3B (Protein Phosphatase 2A 48 KDa Regulatory Subunit (PPP2R3B))

Andere Bezeichnung: PPP2R3B

Hintergrund:

Targeted Subunit: B

Background Information: Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. PPP2R3B belongs to the B'' family. The B'' family has been further divided into subfamilies. PPP2R3B belongs to the beta subfamily of regulatory subunit B''.Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the beta subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene Name: Protein phosphatase 2, regulatory subunit B'', beta

Alternative Symbols: PR48, PR70, NYREN8, PPP2R3L, PPP2R3LY

Protein Name: Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta

Molekulargewicht: 65kDa

Gen-ID: 28227

NCBI Accession: NP_037371

UniProt: Q9Y5P8

Pathways: PI3K-Akt Signalweg, Mitotic G1-G1/S Phases