CD8B Antikörper (N-Term)

Produktnummer ABIN2775290

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch CD8B in WB. Es zeigt Reaktivität gegenüber Proben von Human, Ratte, Hund, Pferd und Meerschweinchen.

Kurzübersicht für CD8B Antikörper (N-Term) (ABIN2775290)

Target: CD8B (CD8b Molecule (CD8B))

Reaktivität: Human, Ratte, Hund, Pferd, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CD8B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-CD8B Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: CD8B Antibody - N-terminal region

Sequenz: RIYWLRQRQA PSSDSHHEFL ALWDSAKGTI HGEEVEQEKI AVFRDASRFI

Homologie: Dog: 93%, Guinea Pig: 86%, Horse: 86%, Human: 100%, Rat: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against CD8B. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CD8B

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8096581

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu CD8B

Target: CD8B (CD8b Molecule (CD8B))

Andere Bezeichnung: CD8B

Hintergrund:

Background Information: The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. CD8B is the CD8 beta chain isoforms.The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified.

Gene Name: CD8b molecule

Alternative Symbols: LY3, P37, LEU2, LYT3, CD8B1

Protein Name: Putative uncharacterized protein CD8B1 EMBL AAY24019.1

Molekulargewicht: 27kDa

Gen-ID: 926

NCBI Accession: NP_742097

UniProt: Q53QL8

Pathways: T-Zell Rezeptor Signalweg