NR1I2 Antikörper (N-Term)

Produktnummer ABIN2774988

Produktdetails anti-NR1I2 Antikörper

Target: NR1I2 (Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2))

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NR1I2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: KKEMIMSDEA VEERRALIKR KKSERTGTQP LGVQGLTEEQ RMMIRELMDA

Homologie: Human: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against NR1I2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human NR1I2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 434 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-NR1I2 Antikörper (ABIN2774988)

Sivertsson, Edebert, Palmertz, Ingelman-Sundberg, Neve: "Induced CYP3A4 expression in confluent Huh7 hepatoma cells as a result of decreased cell proliferation and subsequent pregnane X receptor activation." in: Molecular pharmacology, Vol. 83, Issue 3, pp. 659-70, (2013) (PubMed).

Dou, Zhang, Zhang, Sun, Ding, Chou, Wang, Mani: "Chrysin ameliorates chemically induced colitis in the mouse through modulation of a PXR/NF-?B signaling pathway." in: The Journal of pharmacology and experimental therapeutics, Vol. 345, Issue 3, pp. 473-82, (2013) (PubMed).

Details zu NR1I2

Target: NR1I2 (Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2))

Andere Bezeichnung: NR1I2 (NR1I2 Produkte)

Hintergrund: NR1I2 belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. NR1I2 contains a zinc finger domain.NR1I2 is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. NR1I2 belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.
Alias Symbols: BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR
Protein Interaction Partner: NCOA1, RPS6KB1, UBC, RBBP7, DDB1, UBR5, DYRK2, NCOR2, SDF4, NCOA3, TFAP2C, MAPK7, NFATC4, HSP90AA1, FGR, ATP6AP1, RXRA, RBCK1, NCOA2, SUMO1, SUMO2, SUMO3, NCOA6, SRC, RXRG, RXRB, CHMP1A, NUCB2, ACTN2, PPARGC1A, EIF3I, TADA3, NCOR1, PRMT1, NR1I2, PSMC5, PO
Protein Size: 434

Molekulargewicht: 50 kDa

Gen-ID: 8856

NCBI Accession: NM_003889, NP_003880

UniProt: O75469

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway