GJB2 Antikörper (N-Term)

Produktnummer ABIN2774858

Der Kaninchen Polyklonal anti-GJB2 Antikörper wird verwendet zum Nachweis von GJB2 in Proben von Human, Maus, Ratte, Hund, Rind (Kuh), Meerschweinchen, Pferd, Kaninchen und Schaf. Er wurde validiert für WB.

Kurzübersicht für GJB2 Antikörper (N-Term) (ABIN2774858)

Target: GJB2 (Gap Junction Protein, beta 2, 26kDa (GJB2))

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Meerschweinchen, Pferd, Kaninchen, Schaf

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GJB2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-GJB2 Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: GJB2 Antibody - middle region

Sequenz: STPALLVAMH VAYRRHEKKR KFIKGEIKSE FKDIEEIKTQ KVRIEGSLWW

Homologie: Cow: 86%, Dog: 100%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 86%, Rabbit: 79%, Rat: 93%, Sheep: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against GJB2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human GJB2

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP36608-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu GJB2

Target: GJB2 (Gap Junction Protein, beta 2, 26kDa (GJB2))

Andere Bezeichnung: GJB2

Hintergrund:

Background Information: Gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels. Proteins, called connexins, purified from fractions of enriched gap junctions from different tissues differ. The connexins are designated by their molecular mass. Another system of nomenclature divides gap junction proteins into 2 categories, alpha and beta, according to sequence similarities at the nucleotide and amino acid levels. For example, CX43 (MIM 121014) is designated alpha-1 gap junction protein, whereas CX32 (GJB1, MIM 304040) and CX26 are called beta-1 and beta-2 gap junction proteins, respectively. This nomenclature emphasizes that CX32 and CX26 are more homologous to each other than either of them is to CX43.

Gene Name: Gap junction protein, beta 2, 26 kDa

Alternative Symbols: HID, KID, PPK, BAPS, CX26, DFNA3, DFNB1, NSRD1, DFNA3A, DFNB1A

Protein Name: Gap junction beta-2 protein

Molekulargewicht: 25kDa

Gen-ID: 2706

NCBI Accession: NP_003995

UniProt: P29033

Pathways: Sensory Perception of Sound, Cell-Cell Junction Organization