MKRN1 Antikörper (N-Term)

Produktnummer ABIN2774707

Produktdetails anti-MKRN1 Antikörper

Target: MKRN1 (Makorin Ring Finger Protein 1 (MKRN1))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Hund, Rind (Kuh), Meerschweinchen, Pferd, Ratte, Kaninchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MKRN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: GDRCRYEHSK PLKQEEATAT ELTTKSSLAA SSSLSSIVGP LVEMNTGEAE

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 83%, Rat: 100%, Zebrafish: 77%

Produktmerkmale: This is a rabbit polyclonal antibody against MKRN1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human MKRN1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 147 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu MKRN1

Target: MKRN1 (Makorin Ring Finger Protein 1 (MKRN1))

Andere Bezeichnung: MKRN1 (MKRN1 Produkte)

Synonyme: MKRN1 antikoerper, MGC84269 antikoerper, mkrn1 antikoerper, Makorin-1 antikoerper, RNF61 antikoerper, RFP antikoerper, makorin ring finger protein 1 antikoerper, E3 ubiquitin-protein ligase makorin-1 antikoerper, makorin ring finger protein 1 S homeolog antikoerper, makorin, ring finger protein, 1 antikoerper, MKRN1 antikoerper, LOC100393879 antikoerper, mkrn1.S antikoerper, Mkrn1 antikoerper

Hintergrund: The Makorin ring finger protein-1 gene (MKRN1) is a highly transcribed, intron-containing source for a family of intronless mammalian genes encoding a novel class of zinc finger proteins. Phylogenetic analyses indicate that the MKRN1 gene is the ancestral founder of this gene family.The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases.
Alias Symbols: FLJ21334, RNF61
Protein Interaction Partner: UBC, TP53, CDKN1A, FADD, MAP1LC3B, UBE2W, DUSP23, CSNK1G1, UBE2D3, TERT, EXOSC8,
Protein Size: 147

Molekulargewicht: 16 kDa

Gen-ID: 23608

NCBI Accession: NM_003338, NP_038474

UniProt: Q9UHC7

Pathways: Chromatin Binding