FBXO2 Antikörper (C-Term)

Produktnummer ABIN2774692

Produktdetails anti-FBXO2 Antikörper

Target: FBXO2 (F-Box Protein 2 (FBXO2))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Hund, Pferd, Rind (Kuh), Meerschweinchen, Zebrafisch (Danio rerio), Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FBXO2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: LAEFATGQVA VPEDGSWMEI SHTFIDYGPG VRFVRFEHGG QDSVYWKGWF

Homologie: Cow: 92%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 85%, Rat: 93%, Zebrafish: 77%

Produktmerkmale: This is a rabbit polyclonal antibody against Fbxo2. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 297 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu FBXO2

Target: FBXO2 (F-Box Protein 2 (FBXO2))

Andere Bezeichnung: Fbxo2 (FBXO2 Produkte)

Synonyme: FBG1 antikoerper, FBX2 antikoerper, Fbs1 antikoerper, NFB42 antikoerper, OCP1 antikoerper, Fbs2 antikoerper, Prpl4 antikoerper, F-box protein 2 antikoerper, FBXO2 antikoerper, Fbxo2 antikoerper

Hintergrund: Fbxo2 is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type.
Alias Symbols: FBG1, FBX2, Fbs1, Fbs2, MGC54895, NFB42, Prpl4
Protein Interaction Partner: Stat1, Cul1, Skp1a, Bace1, Vcp,
Protein Size: 297

Molekulargewicht: 34 kDa

Gen-ID: 230904

NCBI Accession: NM_176848, NP_789818

UniProt: Q80UW2