RNF139 Antikörper (N-Term)

Produktnummer ABIN2774685

Dieser Kaninchen Polyklonal Antikörper erkennt spezifisch RNF139 in WB. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte, Hund, Rind (Kuh), Meerschweinchen, Kaninchen und Pferd.

Kurzübersicht für RNF139 Antikörper (N-Term) (ABIN2774685)

Target: RNF139 (Ring Finger Protein 139 (RNF139))

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Meerschweinchen, Kaninchen, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RNF139 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-RNF139 Antikörper

Bindungsspezifität: N-Term

Sequenz: SQRSLFKFYT YSSAFLLAAT SVLVNYYASL HIDFYGAYNT SAFGIELLPR

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 87%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against RNF139. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human RNF139

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 664 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu RNF139

Target: RNF139 (Ring Finger Protein 139 (RNF139))

Andere Bezeichnung: RNF139

Hintergrund: RNF139 is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP. The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP.
Alias Symbols: HRCA1, MGC31961, RCA1, TRC8
Protein Interaction Partner: HM13, HLA-C, UBE2G2, AUP1, UBC, INSIG1, HMGCR, INSIG2, TMUB1, ERLIN2, ERLIN1, SCAP, SEC24B, SREBF2, EIF3A, UBE2U, UBE2Z, UBE2H, COPS5, VHL,
Protein Size: 664

Molekulargewicht: 76 kDa

Gen-ID: 11236

NCBI Accession: NM_007218, NP_009149

UniProt: Q8WU17