CXCL12 Antikörper (Middle Region)

Produktnummer ABIN2774605

Es gibt 1 Publikation für dieses Produkt. Der Kaninchen Polyklonal anti-CXCL12 Antikörper wird verwendet zum Nachweis von CXCL12 in Proben von Ratte, Hund, Rind (Kuh) und Schwein. Er wurde validiert für WB.

Kurzübersicht für CXCL12 Antikörper (Middle Region) (ABIN2774605)

Target: CXCL12 (Chemokine (C-X-C Motif) Ligand 12 (CXCL12))

Reaktivität: Ratte, Hund, Rind (Kuh), Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CXCL12 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-CXCL12 Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: CXCL12 Antibody - middle region

Sequenz: VKHLKILNTP NCALQIVARL KNNNRQVCID PKLKWIQEYL EKALNKRFKM

Homologie: Cow: 90%, Dog: 100%, Pig: 100%, Rat: 90%

Produktmerkmale: This is a rabbit polyclonal antibody against CXCL12. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CXCL12

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-CXCL12 Antikörper (ABIN2774605)

Yin, Seeberger: "Applications of heparin and heparan sulfate microarrays." in: Methods in enzymology, Vol. 478, pp. 197-218, (2010) (PubMed).

Details zu CXCL12

Target: CXCL12 (Chemokine (C-X-C Motif) Ligand 12 (CXCL12))

Andere Bezeichnung: CXCL12

Hintergrund:

Background Information: Stromal cell-derived factors 1-alpha and 1-beta are small cytokines that belong to the intercrine family, members of which activate leukocytes and are often induced by proinflammatory stimuli such as lipopolysaccharide, TNF, or IL1. The intercrines are characterized by the presence of 4 conserved cysteines which form 2 disulfide bonds. They can be classified into 2 subfamilies. In the CC subfamily, which includes beta chemokine, the cysteine residues are adjacent to each other. In the CXC subfamily, which includes alpha chemokine, they are separated by an intervening amino acid. The SDF1 proteins belong to the latter group.

Gene Name: Chemokine (C-X-C motif) ligand 12

Alternative Symbols: IRH, PBSF, SDF1, TLSF, TPAR1, SCYB12

Protein Name: Stromal cell-derived factor 1

Molekulargewicht: 11 kDa

Gen-ID: 6387

NCBI Accession: NP_000600

UniProt: P48061

Pathways: Regulation of Cell Size, CXCR4-mediated Signaling Events, Negative Regulation of intrinsic apoptotic Signaling