CXCL12 Antikörper (Middle Region)

Produktnummer ABIN2774605

Produktdetails anti-CXCL12 Antikörper

Target: CXCL12 (Chemokine (C-X-C Motif) Ligand 12 (CXCL12))

Bindungsspezifität: Middle Region

Reaktivität: Ratte, Hund, Rind (Kuh), Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CXCL12 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: VKHLKILNTP NCALQIVARL KNNNRQVCID PKLKWIQEYL EKALNKRFKM

Homologie: Cow: 90%, Dog: 100%, Pig: 100%, Rat: 90%

Produktmerkmale: This is a rabbit polyclonal antibody against CXCL12. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CXCL12

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 93 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-CXCL12 Antikörper (ABIN2774605)

Yin, Seeberger: "Applications of heparin and heparan sulfate microarrays." in: Methods in enzymology, Vol. 478, pp. 197-218, (2010) (PubMed).

Details zu CXCL12

Target: CXCL12 (Chemokine (C-X-C Motif) Ligand 12 (CXCL12))

Andere Bezeichnung: CXCL12 (CXCL12 Produkte)

Synonyme: IRH antikoerper, PBSF antikoerper, SCYB12 antikoerper, SDF1 antikoerper, TLSF antikoerper, TPAR1 antikoerper, CINC-1 antikoerper, Gro1 antikoerper, Pbsf antikoerper, Scyb12 antikoerper, Sdf1 antikoerper, Tlsf antikoerper, Tpar1 antikoerper, Fsp antikoerper, KC antikoerper, Mgsa antikoerper, N51 antikoerper, Scyb1 antikoerper, gro antikoerper, sdf-1 antikoerper, sdf1 antikoerper, xSDF-1 antikoerper, SDF-1 antikoerper, cxcl12 antikoerper, sdf-1a antikoerper, sdf1a antikoerper, wu:fa55e10 antikoerper, wu:fc16h12 antikoerper, wu:fj84c02 antikoerper, C-X-C motif chemokine ligand 12 antikoerper, C-X-C motif chemokine ligand 1 antikoerper, chemokine (C-X-C motif) ligand 12 antikoerper, chemokine (C-X-C motif) ligand 1 antikoerper, C-X-C motif chemokine ligand 12 L homeolog antikoerper, chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1) antikoerper, CXCL12 antikoerper, cxcl12 antikoerper, Cxcl1 antikoerper, Cxcl12 antikoerper, cxcl12.L antikoerper, cxcl12a antikoerper

Hintergrund: Stromal cell-derived factors 1-alpha and 1-beta are small cytokines that belong to the intercrine family, members of which activate leukocytes and are often induced by proinflammatory stimuli such as lipopolysaccharide, TNF, or IL1. The intercrines are characterized by the presence of 4 conserved cysteines which form 2 disulfide bonds. They can be classified into 2 subfamilies. In the CC subfamily, which includes beta chemokine, the cysteine residues are adjacent to each other. In the CXC subfamily, which includes alpha chemokine, they are separated by an intervening amino acid. The SDF1 proteins belong to the latter group.
Alias Symbols: IRH, PBSF, SDF1, TLSF, SDF1A, SDF1B, TPAR1, SCYB12
Protein Interaction Partner: DAZAP2, CXCR4, CXCL12, DPP4, CD4, FN1, ELANE, MMP2, CTSG, VCAN, PF4,
Protein Size: 93

Molekulargewicht: 11 kDa

Gen-ID: 6387

NCBI Accession: NM_000609, NP_000600

UniProt: P48061

Pathways: Regulation of Cell Size, CXCR4-mediated Signaling Events, Negative Regulation of intrinsic apoptotic Signaling