PPP1R12A Antikörper (C-Term)
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- Target Alle PPP1R12A Antikörper anzeigen
- PPP1R12A (Myosin Phosphatase, Target Subunit 1 (PPP1R12A))
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Bindungsspezifität
- C-Term
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Reaktivität
- Human, Maus, Ratte, Kaninchen, Rind (Kuh), Hund, Pferd, Meerschweinchen
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser PPP1R12A Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Sequenz
- QDSDENEQEQ QSDTEEGSNK KETQTDSISR YETSSTSAGD RYDSLLGRSG
- Homologie
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 86%, Rabbit: 100%, Rat: 100%
- Produktmerkmale
- This is a rabbit polyclonal antibody against PPP1R12A. It was validated on Western Blot.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the C terminal region of human PPP1R12A
- Top Product
- Discover our top product PPP1R12A Primärantikörper
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 1030 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- PPP1R12A (Myosin Phosphatase, Target Subunit 1 (PPP1R12A))
- Andere Bezeichnung
- PPP1R12A (PPP1R12A Produkte)
- Synonyme
- 1200015F06Rik antikoerper, 5730577I22Rik antikoerper, AA792106 antikoerper, AV099298 antikoerper, D10Ertd625e antikoerper, Mypt1 antikoerper, M130 antikoerper, MBS antikoerper, MYPT1 antikoerper, M110 antikoerper, MBSP antikoerper, protein phosphatase 1, regulatory (inhibitor) subunit 12A antikoerper, protein phosphatase 1 regulatory subunit 12A antikoerper, protein phosphatase 1, regulatory subunit 12A antikoerper, Ppp1r12a antikoerper, PPP1R12A antikoerper
- Hintergrund
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Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase.
Alias Symbols: MBS, MGC133042, MYPT1, M130
Protein Interaction Partner: TP53, UBC, NUAK1, RPA3, RPA2, RPA1, TRIM47, AARSD1, PUS1, P3H1, RPRD1B, XPO5, OSGEP, NSUN2, NUSAP1, TTLL12, NUDT5, ARPC2, ACTR3, CUL1, TPP2, PFDN5, PFDN1, NRD1, PAN2, LATS1, gag, FMNL1, PAXIP1, IDH3G, CDV3, RHOA, LRRK2, ATXN10, SIAH2, FBXO25, ARRB2, ELAVL
Protein Size: 1030 - Molekulargewicht
- 113 kDa
- Gen-ID
- 4659
- NCBI Accession
- NM_002480, NP_002471
- UniProt
- O14974
- Pathways
- M Phase
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