PPP1R12A Antikörper (C-Term)

Produktnummer ABIN2774306

Produktdetails anti-PPP1R12A Antikörper

Target: PPP1R12A (Myosin Phosphatase, Target Subunit 1 (PPP1R12A))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Kaninchen, Rind (Kuh), Hund, Pferd, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PPP1R12A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: QDSDENEQEQ QSDTEEGSNK KETQTDSISR YETSSTSAGD RYDSLLGRSG

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 86%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against PPP1R12A. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human PPP1R12A

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 1030 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu PPP1R12A

Target: PPP1R12A (Myosin Phosphatase, Target Subunit 1 (PPP1R12A))

Andere Bezeichnung: PPP1R12A (PPP1R12A Produkte)

Synonyme: 1200015F06Rik antikoerper, 5730577I22Rik antikoerper, AA792106 antikoerper, AV099298 antikoerper, D10Ertd625e antikoerper, Mypt1 antikoerper, M130 antikoerper, MBS antikoerper, MYPT1 antikoerper, M110 antikoerper, MBSP antikoerper, protein phosphatase 1, regulatory (inhibitor) subunit 12A antikoerper, protein phosphatase 1 regulatory subunit 12A antikoerper, protein phosphatase 1, regulatory subunit 12A antikoerper, Ppp1r12a antikoerper, PPP1R12A antikoerper

Hintergrund: Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase.
Alias Symbols: MBS, MGC133042, MYPT1, M130
Protein Interaction Partner: TP53, UBC, NUAK1, RPA3, RPA2, RPA1, TRIM47, AARSD1, PUS1, P3H1, RPRD1B, XPO5, OSGEP, NSUN2, NUSAP1, TTLL12, NUDT5, ARPC2, ACTR3, CUL1, TPP2, PFDN5, PFDN1, NRD1, PAN2, LATS1, gag, FMNL1, PAXIP1, IDH3G, CDV3, RHOA, LRRK2, ATXN10, SIAH2, FBXO25, ARRB2, ELAVL
Protein Size: 1030

Molekulargewicht: 113 kDa

Gen-ID: 4659

NCBI Accession: NM_002480, NP_002471

UniProt: O14974

Pathways: M Phase