FBXW4 Antikörper (N-Term)

Produktnummer ABIN2774192

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch FBXW4 in WB. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte, Rind (Kuh), Meerschweinchen, Pferd, Kaninchen und Hund.

Kurzübersicht für FBXW4 Antikörper (N-Term) (ABIN2774192)

Target: FBXW4 (F-Box and WD Repeat Domain Containing 4 (FBXW4))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Meerschweinchen, Pferd, Kaninchen, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FBXW4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-FBXW4 Antikörper

Bindungsspezifität: N-Term

Sequenz: RQMPWMQLED DSLYISQANF ILAYQFRPDG ASLNRRPLGV FAGHDEDVCH

Homologie: Cow: 100%, Dog: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against FBXW4. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of human FBXW4

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeat freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu FBXW4

Target: FBXW4 (F-Box and WD Repeat Domain Containing 4 (FBXW4))

Andere Bezeichnung: FBXW4

Hintergrund: This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds, disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22.
Alias Symbols: DAC, FBW4, FBWD4, SHFM3, SHSF3
Protein Size: 325

Molekulargewicht: 35 kDa

Gen-ID: 6468

NCBI Accession: NM_022039, NP_071322

UniProt: P57775