FBXW4 Antikörper (C-Term)

Produktnummer ABIN1881340

Produktdetails anti-FBXW4 Antikörper

Target: FBXW4 (F-Box and WD Repeat Domain Containing 4 (FBXW4))

Bindungsspezifität: AA 341-370, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FBXW4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This FBXW4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 341-370 amino acids from the C-terminal region of human FBXW4.

Klon: RB42400

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-FBXW4 Antikörper (ABIN1881340)

Everman, Morgan, Lyle, Laughridge, Bamshad, Clarkson, Colby, Gurrieri, Innes, Roberson, Schrander-Stumpel, van Bokhoven, Antonarakis, Schwartz: "Frequency of genomic rearrangements involving the SHFM3 locus at chromosome 10q24 in syndromic and non-syndromic split-hand/foot malformation." in: American journal of medical genetics. Part A, Vol. 140, Issue 13, pp. 1375-83, (2006) (PubMed).

Deloukas, Earthrowl, Grafham, Rubenfield, French, Steward, Sims, Jones, Searle, Scott, Howe, Hunt, Andrews, Gilbert, Swarbreck, Ashurst, Taylor, Battles, Bird, Ainscough, Almeida, Ashwell, Ambrose et al.: "The DNA sequence and comparative analysis of human chromosome 10. ..." in: Nature, Vol. 429, Issue 6990, pp. 375-81, (2004) (PubMed).

Details zu FBXW4

Target: FBXW4 (F-Box and WD Repeat Domain Containing 4 (FBXW4))

Andere Bezeichnung: FBXW4 (FBXW4 Produkte)

Synonyme: dac antikoerper, hag antikoerper, hagoromo antikoerper, wu:fk63g06 antikoerper, FBXW4 antikoerper, DAC antikoerper, FBW4 antikoerper, FBWD4 antikoerper, SHFM3 antikoerper, SHSF3 antikoerper, Dac antikoerper, Fbw4 antikoerper, dactylin antikoerper, dactylyn antikoerper, F-box and WD repeat domain containing 4 antikoerper, F-box and WD-40 domain protein 4 antikoerper, fbxw4 antikoerper, FBXW4 antikoerper, Fbxw4 antikoerper

Hintergrund: This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds, disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22.

Molekulargewicht: 46337

NCBI Accession: NP_071322

UniProt: P57775